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“Apprenti·e laborantin·e en biologie” position available at the CIG, starting Aug. 2021

Apprenti·e laborantin·e en biologie

Introduction

Institution d’enseignement et de recherche de premier plan au niveau international, l’UNIL compte près de 5’000 collaboratrices et collaborateurs et 15’500 étudiant·e·s, réparti·e·s entre le campus de Dorigny, et les sites du CHUV et d’Epalinges. En tant qu’employeur, elle encourage l’excellence, la reconnaissance des personnes et la responsabilité.

Présentation

Pour compléter son équipe, le Centre Intégratif de Génomique (CIG) de la Faculté de Biologie et de Médecine (FBM) est à la recherche d’un·e Apprenti·e laborantin·e en biologie

Informations liées au poste

Entrée en fonction : 01.08.2021
Durée du contrat : 3 ans
Taux d’activité : 100%
Lieu de travail : Bâtiment Génopode, Quartier Sorge – UNIL, 1015 Lausanne

Site internet de l’UNIL dédié à l’apprentissage: www.unil.ch/srh/apprentissage
Site internet du CIG: https://unil.ch/cig/home.html

Vos activités

Un apprentissage passionnant vous attend dans un cadre de travail exceptionnel, en mouvement constant et dans un environnement multiculturel.

Au sein de notre institut, les laborantin·e·s option biologie participent à des travaux de recherche fondamentale dans les domaines variés (par exemple maladies génétiques rares, évolution du système olfactif, exploration des rythmes circadiens) dans des modèles différents (par exemple: plantes, drosophiles, souris, levures, etc…).
Les apprenti·e·s effectuent un parcours au sein de différents groupes de recherche pour suivre des stages qui couvrent les techniques nécessaires à l’apprentissage de la profession.

Votre profil

  • Avoir achevé sa scolarité obligatoire
  • Être à l’aise avec le calcul et les sciences naturelles
  • Être habile de ses mains
  • Être curieux·se, consciencieux·se et persévérant·e
  • Être capable d’autonomie mais aussi de travailler en équipe
  • Avoir envie de pratiquer l’anglais au quotidien

Vos avantages

Un encadrement professionnel au sein d’un environnement académique multiculturel et varié.

Pour tout renseignement complémentaire

Madame Fabienne Lammers
Responsable des apprentis laborantins au CIG (UNIL)
fabienne.lammers@unil.ch
tél : 021 692 4136

Votre dossier de candidature

Délais de candidature: 29.11.2020

Nous vous prions de bien vouloir nous transmettre votre dossier complet (CV, lettre de motivation, copies des bulletins de notes des 3 dernières années et éventuelles attestations de stage) en format PDF.
Nous vous remercions de prendre note qu’il ne sera pris en compte que les candidatures adressées par le biais de ce site.Remarques

L’UNIL s’engage pour l’égalité.
www.unil.ch/egalite

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Postdoctoral position in Developmental Neurobiology, IBV, Nice (FR)

A postdoctoral position is available from January 2021 in the “Development and Function of Brain Circuits” team led by M. Studer. We aim to understand how rare genetic variants of key master genes of brain development and circuit assembly can cause neurodevelopmental diseases (NDDs). The project will determine the impact of missense variants identified in the NR2F1 gene on the heterogeneity of neurodevelopmental defects described in affected patients. The postdoc will study genotype and phenotype correlations by using CRISPR/Cas9 gene editing in vivo and decipher the pathological contribution of representative variants in the mouse system. We expect that the results

of this work using experimental systems as well as the identification of Nr2f1 direct targets and interacting partners will help in understanding the phenotypic heterogeneity of patients and unveil pathophysiological mechanisms common to multiple NDDs.

Location

The team is located in the heart of Nice and is part of the the Institute of Biology Valrose (27 teams; 300 people; 25 nationalities), an international research centre that brings together high-profile teams with complementary areas of expertise and with a common interest in translating basic research into knowledge for the clinic. The iBV provides state of the art core facilities, with a collaborative and lively atmosphere in a gorgeous city/region. For more information, visit http://ibv.unice.fr/EN/institute/presentation.php

Qualification and experience

We are seeking highly motivated young candidates holding a PhD for less than 2 years. Preference will be given to applicants with a background in mouse genetics, cellular and molecular biology, confocal imaging and genome wide approaches. The position is opened for one year renewable up to 3 years (including medical benefits) starting as early as January 2021. Fluency in English is mandatory but ability to speak French is not required.

Applications

Applications should contain a CV, a letter of motivation with a description of research accomplishments (2 pages max) and the contact information of two references able to recommend their research work directly to Michele.STUDER@unice.fr.

Selected related publications :
1. Bertacchi M. et al., EMBO J. 2020 Jun 2. PMID: 32484994
2. Bertacchi M. et al., EMBO Mol Med. 2019 Jul 18. PMID: 31318166
3. Bertacchi M. et al., Review, Brain Res. 2018, Apr 27. PMID: 29709504.
4. Bosch D.G.et al., Am J Hum Genet 2014, Feb 6.. PMID: 24462372

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Thesis defense of Kaan Mika, Friday Nov. 6, 2020 – 4:30 pm in Aud. B, Génopode

Kaan Mika  will present his public thesis defense entitled: “Identification of regulatory factors involved in the singular expression of members of an olfactory receptor gene cluster”. The presentation will be held in English and it will take place on Friday November 6th 2020 at 16h30 at Genopode building (UNIL), Auditorium B.

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EMBO J.: co-auth.: M.Quadroni

EMBO J.  2020 Oct 19;e104500. doi: 10.15252/embj.2020104500. Online ahead of print.

Human shelterin protein POT1 prevents severe telomere instability induced by homology-directed DNA repair

Galina Glousker 1Anna-Sophia Briod 1Manfredo Quadroni 2Joachim Lingner 1

Abstract

The evolutionarily conserved POT1 protein binds single-stranded G-rich telomeric DNA and has been implicated in contributing to telomeric DNA maintenance and the suppression of DNA damage checkpoint signaling. Here, we explore human POT1 function through genetics and proteomics, discovering that a complete absence of POT1 leads to severe telomere maintenance defects that had not been anticipated from previous depletion studies in human cells. Conditional deletion of POT1 in HEK293E cells gives rise to rapid telomere elongation and length heterogeneity, branched telomeric DNA structures, telomeric R-loops, and telomere fragility. We determine the telomeric proteome upon POT1-loss, implementing an improved telomeric chromatin isolation protocol. We identify a large set of proteins involved in nucleic acid metabolism that engage with telomeres upon POT1-loss. Inactivation of the homology-directed repair machinery suppresses POT1-loss-mediated telomeric DNA defects. Our results unravel as major function of human POT1 the suppression of telomere instability induced by homology-directed repair.

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Seminars of candidates for SNSF Eccellenza assistant professor with fellowship, 22-23.10.2020

To access the webminars: https://unil.zoom.us/j/96630540114

Thursday Oct. 22

9h00: Nicolas Battich,  Hubrecht Institute, Utrecht (NL)
“The lifecycle of mRNAs at the single-cell level”
10h00: interview with PIs only (all other participants are requested to leave the meeting)

15h00: Lena van Giesen, Harvard University, Cambridge (USA)
“Molecular basis of chemo tactile sensation in Octopus”
16h00: interview with PIs only (all other participants are requested to leave the meeting)

17h00: Samira Asgari, Harvard Medical School, Harvard (USA)
“Leveraging population differences to learn about the genetic basis of complex traits”
18h00: interview with PIs only (all other participants are requested to leave the meeting)

Friday Oct. 23

15h00: Laurence Lemaire, Lewis Sigler institute for integrative genomics, Pinceton University (USA)
“From single cell transcriptome lineages to a gene regulatory brain map: Identification of the proto-hypothalamic territory”
16h00: interview with PIs only (all other participants are requested to leave the meeting)

17h00: Alessandro De Simone, Duke University Medical Center, Durham (USA)
“Listening to the scale-beat: signalling waves and tissue morphogenesis in zebrafish regeneration.”
18h00: interview with PIs only (all other participants are requested to leave the meeting)

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Group leader opportunities at the MRC Human Genetics Unit, Uni. of Edingurgh (UK)

The MRC Human Genetics Unit, University of Edinburgh, is recruiting new PI group leaders and programme leader track PIs to enhance and enrich its strategic research goals.

Further information on the MRC human genetics unit: https://www.ed.ac.uk/mrc-human-genetics-unit