PLoS Biol.: co-auth.: B.Thorens

PLoS Biol. 2023 Sep 21;21(9):e3002308.  doi: 10.1371/journal.pbio.3002308. eCollection 2023 Sep.

Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing

Francisco Nualart 1 2Manuel Cifuentes 3Eder Ramírez 2Fernando Martínez 1María José Barahona 2Luciano Ferrada 2Natalia Saldivia 1Ernesto R Bongarzone 4Bernard Thorens 5Katterine Salazar 1


Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose-sensing mechanisms and feeding behavior in the hypothalamus. Here, we discuss how hyperglycemia temporarily modifies ependymal cell ciliary beating to increase hypothalamic glucose sensing. A high level of glucose in the rat CSF stimulates glucose transporter 2 (GLUT2)-positive subcommissural organ (SCO) cells to release SCO-spondin into the dorsal third ventricle. Genetic inactivation of mice GLUT2 decreases hyperglycemia-induced SCO-spondin secretion. In addition, SCO cells secrete Wnt5a-positive vesicles; thus, Wnt5a and SCO-spondin are found at the apex of dorsal ependymal cilia to regulate ciliary beating. Frizzled-2 and ROR2 receptors, as well as specific proteoglycans, such as glypican/testican (essential for the interaction of Wnt5a with its receptors) and Cx43 coupling, were also analyzed in ependymal cells. Finally, we propose that the SCO-spondin/Wnt5a/Frizzled-2/Cx43 axis in ependymal cells regulates ciliary beating, a cyclic and adaptive signaling mechanism to control glucose sensing.

Life Sciences Switzerland (LS2) – Deadline for abstract submission: Nov. 8, 2023

  • Deadline for abstract submission (posters and talks)8 November 2023
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The program of this edition gathers an amazing panel of keynote speakersPr. Nicole King from the University of California, Berkeley (US), Dr. Samer Hattar from the National Institute of Mental Health (US), and Dr. Pavel Tomancakfrom the Max Planck Institute of Molecular Cell Biology and Genetics (DE) and Dr. Melina Schuh from the Max Planck Institute for Multidisciplinary Sciences (DE), who will give a keynote lecture at the Young Scientists’ Satellite.

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The International Max Planck Research School for Living Matter (IMPRS-LM) is looking for talented and motivated PhD candidates of all nationalities with a background in MOLECULAR and CELL BIOLOGY, BIOCHEMISTRY, BIOPHYSICS, APPLIED and THEORETICAL PHYSICS, CHEMICAL BIOLOGY, STRUCTURAL BIOLOGY, SYSTEMS BIOLOGY and related fields.

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