ext. job openings Archive

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Professorship position open in RNA Control in the Cardiovascular System at the Cardiopulmonary Institute (CPI), University of Frankfurt (DE)

The Medical Faculty of Johann Wolfgang Goethe University Frankfurt am Main invites applications for the following position as a civil servant, which is funded by the Tenure Track Programme of the German Federal Government and the Federal States (BLP-TT), starting at the earliest possible date:

Professorship (W1, tenure track) for RNA Control in the Cardiovascular System at the Cardiopulmonary Institute (CPI)

The initial tenure track appointment as professor is for six years according to § 64 of the Higher Education Act of the State of Hessen (HHG). The invitation to apply aims to reach early-stage researchers, who have finished their doctorate. Candidates should not have obtained their PhD at Goethe University Frankfurt or should have worked as a researcher at an external institution for at least two years after their PhD. The doctorate should not date back to more than four years, in case of a completion of residency not more than seven years. Upon positive evaluation, the incumbent will be promoted to a permanent position at a higher level (W2).

The CPI is a joint research institute of Goethe University Frankfurt, Justus Liebig University Giessen and the Max Planck Society, supported by the German Cluster of Excellence Strategy Programme. The CPI’s aim is to make groundbreaking contributions to cardiopulmonary science with the long-term goal of reducing morbidity and mortality in cardiopulmonary diseases.

Complete job description: RNA_Cardiovascular_Professorship_Frankfurt

Link to candidate: http://www.uni-frankfurt.de/45303084/Ausschreibungen_von_Professuren___Fachbereich_15___Biowissenschaften#exnage_en 

Procedure of application: http://www.uni-frankfurt.de/62612559/Information_Sheet_for_the_Application_for_a_Professorship.pdf 

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Post doctoral fellow position available in ICR, London (UK)

Post-doctoral Training Fellow in forecast drug resistance in cancer

01/10/2019, 23:55
Sutton
Molecular Pathology
Evolutionary Genomics & Modelling
Full time
Fixed Term
3 years
35
£32,200 – £42,550
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

The Centre for Evolution and Cancer within the Institute of Cancer Research is supported by a Strategic Award from the Wellcome Trust. We focus on interrogating clonal evolution in tumours by studying the dynamics of heterogeneous cancer cell populations and their microenvironment. We make use of multi-region genomic profiling, single-cell genetics, computational histopathological analysis and mathematical modelling to reconstruct the past evolutionary history of tumours and predict their future.

 

Dr Andrea Sottoriva’s lab, in collaboration with the Greaves and Valeri’s labs at the ICR and other research laboratories in the UK and Italy, has been awarded the CRUK Accelerator Award entitled “Single cell cancer evolution in the clinic”.

 

The aim of the collaboration is to deliver tools and devices that could be promptly implemented in a clinical setting to pre-emptively intercept treatment resistance in individual cancer patients. The team combines cancer evolutionary modelling, new single-cell approaches, novel microfluidic devices, patient-derived organoid models, and new data integration techniques with the aim of providing comprehensive single-cell portraits of patient samples, before and after treatment.

 

For this position, we are seeking a highly motivated Postdoctoral Training Fellow with expertise in molecular and cellular biology applied to cancer evolution to work on forecasting drug resistance in cancer. The responsibilities include tissue culture of cancer model systems, specifically cell lines and patient-derived organoids, drug screening, lentiviral transfection, next-generation sequencing, and single-cell genomic profiling of samples from patients and models. The post will be responsible for designing and running experimental evolution assays in cancer model systems and study the emergence of resistance do novel drugs in the context of intra-tumour heterogeneity and clonal evolution. The successful candidate will work closely with a diverse team to formulate hypotheses and validate predictions using quantitative assays.

 

Applicants should have a good first degree in biology, biotechnology, or similar and a PhD in cancer biology or similar. Applicants must have experience with cancer model systems, drug screening, and have a good publication record. Experience with next-generation sequencing is highly desirable. Experience with animal models would also be advantageous. Excellent organizational and communication skills are essential.

 

The position is offered on a 3 year fixed term contract. The full salary range for the post is £32,200 – £42,550 p.a. inclusive. Starting salary on the scale will be based on previous postdoctoral experience.

 

Informal enquiries can be made to Dr Andrea Sottoriva (andrea.sottoriva@icr.ac.uk). Please DO NOT send your application via email, formal applications must be submitted online.

 

To apply please complete an application form online, including supporting statement section and two referees contact details and upload your CV

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.

Additional Documentation for Candidates

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 3 open positions available at the Institute of Genomics, University of Tartu (EE)

Institute of Genomics received H2020 ERA-Chair grant in 2018.
The project started from 1st of September 2018 and will last for 5 years.

The proposed ERA Chair – the Center for Genomics, Evolution and Medicine (cGEM), aims to apply advancements in genomic medicine in an evolutionarily-aware framework to account for different evolutionary pathways of populations which have led to differences in susceptibility to common diseases. cGEM group (http://cgem.ut.ee), led by Dr Anders Eriksson, was recently formed with the goal to bridge the fields of bioinformatics, evolutionary biology and genomic medicine. The research in the cGEM ERA Chair group will be focussed on combining tools and data from different disciplines to gain insights into the genetic variation, regulatory mechanisms for gene expression and gene-environment interactions responsible for variation in complex human traits and susceptibility to disease within and between and populations, and translating these insights into clinical practise and collaboration with industry.

 

Who do we need?

Senior Research Fellow of Evolutionary and Population Genomics

researcher in evolutionary genetics, population genetics, computational genetics and genomics or related fields

 

Senior Research Fellow of Bioinformatics and Medical Genomics

researcher in medical and functional genetics, bioinformatics, personalised medicine or related fields

 

Senior Research Fellow of Molecular Medicine (position under Institute of Clinical Medicine)

researcher in medical genetics and diagnostics, molecular medicine, and/or clinical research or related fields

 

What do we offer?

The recruitment package includes a competitive salary, fully funded positions for one postdoc and one PhD student to complete the team. It is a 4-year position starting from 1st of November 2019 to 31rd of August 2023, which can be extended if successful.

 

How to apply?

Applications should include a letter of application, CV, motivation letter, list of research publications, research agenda including contacts of two references and a copy of a document which shows the candidate to hold the required qualification. In your publication list, please explain briefly the relevance of your most important work.

In order to be considered for the position, the candidate must submit required documents to the UT Human Resources Office (email: personal@ut.ee) at the latest on 16.09.2019

 

Further Information:

Mait Metspalu, PhD director of Institute of Genomics, mait.metspalu@ut.ee

Andres Salumets, Institute of Clinical Medicine, andres.salumets@ut.ee

Anders Eriksson, PhD, cGEM ERA Chair, group leader genomics guided evolutionary medicine, anders.eriksson@kcl.ac.uk

Merit Kreitsberg, project manager, merit.kreitsberg@ut.ee

 

 

Further information:
Senior Research Fellow of Bioinformatics and Medical Genomics 
Senior Research Fellow of Evolutionary and Population
Senior Research Fellow of Molecular Medicine

 

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2 junior group leader positions open at the NCCR RNA & Disease

The NCCR RNA & Disease seeks for up to 2 young group leaders with innovative research projects to become Junior Principal Investigators of the NCCR RNA & Disease.
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PhD student position available in group Attanasio, University of Leuven (BE)

PHD POSITION: CHROMATIN STRUCTURE ANALYSIS OF RARE INHERITED COPY NUMBER VARIANTS

(ref. BAP-2019-559)

 

The lab of Dr. Attanasio is a new research group at the Department of Human Genetics, KU Leuven (=Leuven University), the highest-ranked university in Belgium and the most innovative university in Europe. The lab performs state-of-the-art research in functional genomics to study the regulatory role of non-coding DNA in complex biological processes and supports other groups with expertise in gene regulation and genomics approaches. The goal is to understand how regulatory sequences control spatio-temporal gene expression programs and how their alteration – through nucleotide or genome structural variation –contributes to human phenotypes or diseases.
Project

Copy-Number Variations (CNVs), which define sequence deletions or insertions of ≥50bp, have been shown to play important roles in population diversity and human diseases. Topologically Associated Domains (TADs) are fundamental regulatory units of the genome as they ensure proper gene expression regulation. Several studies have reported that genomic rearrangements such as deletion or duplication of DNA segments (i.e. CNVs) could disrupt, duplicate or shift TADs boundaries and affect human biology. In this project, we aim at identifying the effects of rare inherited CNVs in families with developmental disorders.

For this project, we are seeking a highly motivated PhD student interested in studying the intersection between structural variants, 3D chromatin architecture and human diseases using high-throughput technologies, genetics, genomics and bioinformatics.

Profile
  • Applicants should hold a Master degree in Biomedical Sciences, BioEngineering or Bioinformatics.
  • Strong interest in the field of non-coding gene regulation and human diseases.
  • Previous research experience in the fields of molecular biology, genomics or chromatin dynamics is preferred. However, we will also consider candidates with a background in computational biology interested in expanding their skill set to wet lab techniques.
  • Bioinformatics training (R, Python) and knowledge of statistics.
  • We are looking for independent, innovative and creative personalities with a hands-on, can-do attitude.
Offer
  • We offer employment as a full-time doctoral researcher in a stimulating environment, but the student will be asked to apply for individual funding (f.e. FWO) at least once.
  • This project is part of a larger research effort involving seven laboratories of the Human Genetics Department of KU Leuven. The candidate will thus have the opportunity to interact with experts in human genetics, bioinformatics and human population genetics.
  • The possibility to participate in international conferences and collaborations.
  • Access to state-of-the-art techniques and infrastructure.
  • A stimulating and diverse international research environment in a world-class academic context, located in the heart of Europe.

Start date: the position will be available from 1st of November, but the starting date is negotiable.

Interested?

For more information please contact Prof. dr. Catia Attanasio, mail: catia.attanasio@kuleuven.be.

Additional required information:

  • Please enclose a motivation letter to your application with a brief research statement that demonstrates your interest in this type of research and a CV.
  • Please provide contact information of 2 mentors who agreed to provide a short letter of recommendation.
You can apply for this job no later than September 22, 2019 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be
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Post-Doctoral Positions at the NIH, Framingham, Massachusetts (USA)

2 Post-Doctoral Positions at the NIH

The Population Sciences Branch (PSB) of the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health invite applications for 2 Post-Doctoral Fellow positions in Dr. Andrew Johnson’s Lab. Dr. Johnson is a tenured NIH Senior Investigator with stable funding, and a research lab based at the historic Framingham Heart Study (FHS). The FHS was started in 1948 with a focus on unlocking the risk factors behind cardiovascular disease. The Johnson Lab is highly focused on understanding platelets and their role in both bleeding and cardiovascular disease, and how we may improve anti-platelet therapeutics. Trainees in the Johnson Lab have gone onto successful careers in industry and academia, and the Lab has >20,000 citations to its work with a current h-index >70.

We seek motivated, creative and bright individuals, to work at the Framingham Heart Study. The FHS, has a wealth of genetic and OMICs data including whole genome sequence data, transcriptomes (microarray and RNA-seq), methylome, lipidome, metabolome, microbiome and proteome. Additionally, the Johnson Lab has led the collection of the largest global samples to date on platelet function and platelet reactivity, both within FHS and other cohort samples. Relevant future research project areas for Fellows include the genetics of platelet function, pharmacogenetics of anti-platelet therapy, integration of platelet transcriptome and other OMICS data with cardiovascular risk and platelet function data, risk prediction of cardiovascular disease based on platelet biomarkers, and the relationship between platelet biomarkers and clinical bleeding history. Additional epidemiological questions relate to how platelets change in aging, ethnic differences in platelet function, the influence of platelet function on cancer risk, and the role of physical activity, dietary intake and other environmental factors on platelet function.

We collaborate widely with several Domestic and International Consortia in the area of Hematology (cell counts), Hemostasis (clotting factors), and cardiovascular risk (MI, stroke, VTE). We are co-leading genetic projects on platelet counts in ~1.2 million individuals in sample size to generate new target genes controlling platelet biogenesis and decay. We partner with stem cell collaborators, zebrafish and mouse geneticists for functional studies to follow up human platelet genetic discoveries.

Applicants must have an M.D. and/or Ph.D. and research experience in 1 or more of the following: Epidemiology, Hematology, Platelet Biology, Statistical Genetics, Genomics, Pharmacogenomics, and/or Bioinformatics. A proven track record of prior publications is expected.

The successful candidate will be offered a competitive salary commensurate with experience and qualifications. The initial appointment will be for a minimum of 2 years, with appointment renewals in 1-year increments. The post-doc must be a US citizen, resident alien, or nonresident alien who obtains a valid employment visa.

Applicants should submit a cover letter highlighting key qualifications and research interests, and curriculum vitae with complete bibliography to:

Andrew D. Johnson, Ph.D. at johnsonad2@nhlbi.nih.gov

The advertisement will remain open until the positions are filled.  PDF versions of documents sent by email are strongly preferred.

HHS and NIH are Equal Opportunity Employers.

Applications from women, minorities and persons with disabilities are strongly encouraged to apply. The NHLBI/NIH is a smoke freeworkplace. The NIH is dedicated to building a diverse community in its training and employment programs.