ext. job openings Archive

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BioInformatician position available in genetic/epigenetic mechanisms controlling immune cells, Milan (IT)

SR-TIGET_BioInfoPosition2019

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Francesca R. Santoni de Sio, PhD

Telethon Institute for Gene Therapy
San Raffaele Scientific Institute
via Olgettina 58, 20132 Milan, Italy
Tel.: +390226434669
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External job opening: Research officer cellular immunology & assay development

For one of our clients, a fast growing Biotherapeutics company located at the Biopole (Lausanne), we are looking for a:

RESEARCH OFFICER
CELLULAR IMMUNOLOGY & ASSAY DEVELOPMENT

ROLE OVERVIEW:

The Research Officer will be responsible of designing, performing and analyzing experiments to support the validation of novel biologic targets in immuno-oncology and autoimmune diseases. We are looking for an experienced, highly collaborative, independent and flexible team player for our high-paced dynamic environment.

RESPONSIBILITIES:

  • Design, optimize and validate functional immuno-oncology assays including but not limited to immunological multi-color cell surface and intracellular flow cytometric profiling, multiplex cytokine profiling, gene expression profiling, binding assays, primary human cell-based assays for the characterization of novel biological candidates.
  • Perform cell culture, including primary human cultures, development and maintenance of cell lines.
  • Write detailed protocols in English.
  • Participate in day-to-day laboratory management.
  • Perform data analysis on a regular basis and clearly communicate results in English.
  • Maintain experimental records in electronic lab notebook format.
  • Collaborate across functions to validate novel targets
  • Assist with general laboratory duties including lab equipment maintenance, ordering and receiving of lab supplies.
  • Comply with all safety guidelines
  • Perform other relevant responsibilities as required.

REQUIREMENTS:

  • Minimum of technical degree or equivalent in immunology, cellular biology or related life sciences
  • 3+ years of laboratory experience (industry experience preferred)
  • Solid and demonstrable bench level experience in the development, validation and implementation of immunological assays
  • Hands-on expertise in methodologies, reagents and instruments used for primary cell cultures, flow cytometry (mandatory), ELISA and cytokine analyses
  • Experience with handling primary cells in BSL-2 level facilities, isolation of immune cells from human biological samples (PBMC) is mandatory
  • Practical knowledge in data analysis using standard software (e.g. Excel, GraphPad, JMP, Flow cytometry dedicated software)
  • Experience in antibody discovery and pharmaceutical industry is a plus
  • Fluent English both written and verbal; proficiency in French is a plus
  • Strong organizational skills with the capacity to handle multiple tasks simultaneously
  • Ability to work independently as well as part of a cross-functional team
  • Strong interpersonal communication skills

 

Any question? Please call Joanna Jones, Head of recruitment: +41 78 619 76 70

Interested? Please apply by e-mail: recruitment@consultantsinscience.com

Consultants in Science
Biopole SC-A
Route de la Corniche 4
CH – 1066 Epalinges

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External job opening: Senior research/s officer/s – antibody discovery- phage display library generation & selection

For one of our clients, a fast growing Biotherapeutics company located at the Biopole (Lausanne), we are looking for a:

SENIOR RESEARCH OFFICER/RESEARCH OFFICERS- ANTIBODY DISCOVERY- PHAGE DISPLAY LIBRARY GENERATION & SELECTION

ROLE OVERVIEW

Our successful candidates will join an innovative antibody/protein engineering department with a strong record of success in developing novel antibody therapeutics in the field of immune- oncology and autoimmune diseases. You will collaborate across the matrix team to design and generate phage display libraries and selections to advance the portfolio.

We invite an interactive and creative individual who possesses sufficient scientific knowledge as well as some strong hands-on experience in phage display to deliver the next wave of novel therapeutics to the patients.

SPECIFIC RESPONSIBILITIES:

  •  Lead, design and execute the generation of synthetic and immune phage display libraries
  •  Perform phage display selections
  •  Participate in phage display screening campaigns
  •  Implement new methods for antibody discovery
  •  Present and discuss data in English in both informal and formal settings
  •  Maintain detailed and organized documentation
  •  Participate in day-to-day laboratory management
  •  Perform other relevant duties as required.
  •  Collaborate across the matrix to advance the portfolio
  •  Comply with all safety guidelines

REQUIREMENTS:

  • PhD, Master’s / Bachelor’s degree in molecular biology, biochemistry, biotechnology or    other related fields
  •  At least 2-3 years of experience in a relevant industry/academic setting
  •  Experience in antibody phage display library generation and selection
  •  Proficiency in molecular biology techniques (RNA extraction, RT-PCR, PCR, cloning, primer
  • design) and DNA sequence analysis software
  •  Experience with flow cytometry and ELISA methods
  •  Knowledge of immune library cloning and next generation sequencing (NGS) is a plus
  •  Strong English communication skills, both oral and written
  •  Rigorous, excellent organization skills, autonomous, hands-on and team minded
  •  Strong interpersonal communication skills and the ability to present to all levels of the
  • organization
  •  Proven experience in problem analysis/solving
  •  Proactive, reactive and adaptable

Any question? Please call Joanna Jones, Head of recruitment: +41 78 619 76 70

Interested? Please apply by e-mail: recruitment@consultantsinscience.com

Consultants in Science
Biopole SC-A
Route de la Corniche 4
CH – 1066 Epalinges

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External job opening: Principal scientist cellular immunology & assay development

For one of our clients, a fast growing Biotherapeutics company located at the Biopole (Lausanne), we are looking for a:

PRINCIPAL SCIENTIST
CELLULAR IMMUNOLOGY & ASSAY DEVELOPMENT

ROLE OVERVIEW:
To lead validation of novel biological targets, performing and analyzing experiments in the field of immune- oncology and autoimmune diseases to deliver the next wave of novel therapeutic concepts. We are looking for an experienced, independent and flexible team player.

RESPONSIBILITIES:

  • Lead the identification and validation of new therapeutic concepts to build the portfolio in immuno- oncology and autoimmune diseases.
  • Lead, develop, perform and analyze immunological assays including but not limited to immuno- oncology assays such as immune profiling using multi-color flow cytometry, multiplex cytokine profiling, gene expression profiling, ELISA, binding assays and functional primary human cell-based assays for the characterization of novel biological candidates.
  • Perform cell culture, including primary human cultures, development and maintenance of cell lines.
  • Contribute to inter-disciplinary research efforts in a cross-functional setting.
  • Design, perform and analyze experiments and communicate results in a timely manner.
  • Maintain experimental records in electronic laboratory notebook format.
  • Review relevant scientific literature, experimental design, troubleshooting, analysis and interpretation of data
  • Assist with general laboratory duties including lab equipment maintenance, ordering and receiving of lab supplies.
  • Lead external collaborations to build the portfolio as needed
  • Comply with all safety guidelines
  • Perform other relevant responsibilities as required.
  • Manage a small team of direct reports

 

REQUIREMENTS:

  • PhD (entry level) or Master’s degree in immunology, cellular biology or related life sciences with at least 5 years of experience in drug discovery
  • Solid and demonstrable bench level experience in the development, validation and implementation of immunological assays
  • Hands-on expertise in methodologies, reagents and instruments used for primary cell cultures, flow cytometry (mandatory), ELISA and cytokine analyses
  • Experience with handling primary cells in BSL-2 level facilities, isolation of immune cells from human biological samples (PBMC) is mandatory. Practical knowledge in data analysis using standard software (e.g. Excel, GraphPad, JMP, Flow cytometry dedicated software)
  • Experience in antibody discovery and pharmaceutical industry is a plus
  • Excellent written and verbal communication skills in English; proficiency in French is a plus
  • Strong organizational skills with the capacity to handle multiple tasks simultaneously
  • Ability to work independently as well as part of a cross-functional team
  • Strong interpersonal communication skills
  • Excellent lab management skills and mentoring skills
  • Strong work ethic and willingness to participate in a fast-paced work environment

 

Any question? Please call Joanna Jones, Head of recruitment: +41 78 619 76 70

Interested? Please apply by e-mail: recruitment@consultantsinscience.com

Consultants in Science
Biopole SC-A
Route de la Corniche 4
CH – 1066 Epalinges

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External job opening: Senior Research Officer – Protein Technologies Automation

For one of our clients, a fast growing Biotherapeutics company located at the Biopole (Lausanne), we are looking for a:

Senior Research Officer – Protein Technologies Automation

 

ROLE OVERVIEW

The successful candidate will have a demonstrated expertise in protein purification with focus on antigens, antibodies, and bi/multispecific antibodies. The primary purpose of this role is to support discovery. The candidate will be responsible for processing of mammalian-expressed recombinant proteins through the use of state-of-the-art technologies and automated equipment. The position is laboratory-based within the Protein Sciences group.  

Specific Responsibilities:

  • Design and implement automation strategies for high-throughput purification of antigens, antibodies, and bi/multispecific antibodies
  • Develop efficient purification protocols
  • Be a hands-on presence in the laboratory
  • Specify, purchase, install and maintain robotic equipment
  • Write formal technical reports, methods and procedures
  • Train personnel on use of equipment and methods
  • Support data and method transfer within/outside the department
  • Accomplish goals under project team timelines
  • Interface with multiple discovery project and matrix teams across the organization
  • Effectively manage projects and resources to maximize progress
  • Effectively communicate research progress and opportunities to senior management
  • Support publications in high-tier journals and present at international meetings
  • Support a culture that embraces scientific excellence, continuous learning, and increasing team’s ability to deliver novel drug candidates Provide scientific guidance for the protein biochemistry group supporting early discovery

 

Requirements:

  • D. in Analytical Chemistry, Biochemistry or related discipline with demonstrated capabilities in protein purification automation and at least 3 years of relevant experience. MSc with at least 6 years of relevant experience will be considered. Industry experience in antibody purification is preferred
  • A demonstrated record of laboratory automation and scientific accomplishment
  • Proven track record in project delivery
  • Demonstrated technical expertise in protein purification
  • Strong understanding of analytical biochemistry and experience in protein/antibody characterization techniques (e.g. SDS-PAGE, SEC, IEF, DSC, DSF)
  • Strong knowledge in the operation of AKTA and other chromatography systems
  • Experience in operating the Unicorn software package
  • Strong problem-solving and troubleshooting skills. A working knowledge of the repair and maintenance of robotic equipment is desired
  • Strong capabilities in experimental design, execution and data interpretation
  • Ability to work independently
  • Ability to provide scientific guidance, leadership and training to others within/outside the department.
  • Fluency in English, both written and verbal

 

Any question? Please call Joanna Jones, Head of recruitment: +41 78 619 76 70

Interested? Please apply by e-mail: recruitment@consultantsinscience.com

Consultants in Science
Biopole SC-A
Route de la Corniche 4
CH – 1066 Epalinges

 

 

 

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15 Fully funded PhD studentships in Quantitative Biology, UNIL

Introduction

The advent of large-throughput data is transforming life sciences into an increasingly quantitative discipline. The University of Lausanne (Switzerland) is at the forefront of this revolution, with quantitative research ramping up throughout the Faculty of Biology and Medicine, a dedicated department of Computational Biology, and interdisciplinary units such as the Center for Integrative Genomics. UNIL also hosts the headquarters of the Swiss Institute of Bioinformatics, to which many quantitative research groups are affiliated, and closely collaborates with EPFL on the same campus. Ideally situated along the lake of Geneva, near Lausanne’s city center, UNIL brings together over 120 nationalities.

UNIL’s Faculty of Biology and Medicine has a recently launched a doctoral programme entitled “Quantitative Biology”. A wide range of research groups are recruiting PhD students, covering areas as diverse as evolution, synthetic biology, plant science, cancer genomics, microbiology, molecular biology, neuroscience, biological imaging, and computational biology.

Hiring principal investigators include Roman ArguelloRichard BentonSven BergmannGiovanni Ciriello Adrien Depeursinge Paul FrankenMaria-Cristina GambettaJérôme GoudetLaurent KellerZoltán KutalikLiliane MichalikSerge PeletAlexandre ReymondMarc Robinson-RechaviSebastian SoykYuko Ulrich  & Jolanda van Leeuwen .

 

Job information

Expected start date: 01.03.2020 or to be agreed
Contract length: The initial contract is for one year and is extendable to a total of 4-5 years.
Activity rate: 80-100%
Workplace: University of Lausanne, Dorigny

 

 

Your qualifications

We are accepting applications from talented and enthusiastic candidates who are interested in a dynamic, well-supported lab at a top research institution. Candidates need to finish a Master’s degree in a relevant area before the start date of their doctoral studies.

 

We are looking for three main types of PhD students:

  • Students with a life science degree, interested in working in an experimental lab, but with a high degree of motivation to learn the fundamentals of computational biology, and to develop quantitative skills to analyze data more effectively
  • Students with a life science degree interested in working in a dry computational lab, keen to deepen their quantitative skills and broaden their horizon in terms of experimental and computational techniques
  • Students with a non-biological background (e.g. computer science, maths, physics), who are highly motivated to transition to Life Sciences

A high level of written and spoken English proficiency is required since most scientific activities are conducted in English,

 

What the position offers you

You will develop your research project while working in a world competitive, interdisciplinary and highly collaborative environment.

The PhD program in Quantitative Biology provides opportunities for professional training and acquisition of highly transferable skills. This is complemented by a wide range of activities (retreats, symposia, student life).

The position is fully funded. Salary and benefits are internationally highly competitive. Additional funding for consumables, computing, and to attend international conferences is available.

 

Informal inquiries

Prof. Christophe Dessimoz, Director of the UNIL Doctoral Program in Quantitative Biology program
christophe.dessimoz@unil.ch

 

Your application 

Deadline: 15.10.2019

Please, send your full application in Word or PDF through the form linked below.

It should contain:

  • Motivation letter (max. one page)
  • Curriculum vitae including, if available, extracurricular activities, internships, publications, conferences, awards, software contributions, etc.
  • Master’s thesis summary (max. one page)
  • The names and contact details of 2-3 referees

Lab visits and interviews will take place on 3-4 December 2019 in Lausanne.

Submit your application here! 

Further information: https://unil.ch/quantitative-biology/home/menuinst/join-the-qb-program/joint-phd-call-late-2019.html