Seminars & Workshops Archive

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Thesis defense of Khanh Bao Trang, July 11, 2019 – 4:00 pm in Aud. A, Génopode

Khanh Bao Trang will present her public thesis defense entitled: ”Circadian modulation of genome-wide RXR binding in mouse liver tissue ”.

The presentation will take place on Thursday July 11th at 4pm in Auditorium A, Génopode building, UNIL-Sorge.

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Thesis defense of Christopher Dumayne, July 5, 2019 – 3:00 pm in Aud. B, Génopode

Christopher Dumayne will present his public thesis defense entitled: ”Klf6, a novel regulator of ß-cell mass, insulin secretion, and identity”.

The presentation will take place on Friday July 5th at 3pm in Auditorium B, Génopode building, UNIL-Sorge.

The presentation will be followed by an aperitif.

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Dr. Klaas Vandepoele will give a seminar – 12:15 p.m. in Aud. A Génopode, on June 20, 2019

DBC seminar

Dr. Klaas Vandepoele, from the VIB-UGent Center for Plant Systems Biology on June 20th, at 12h15

More about Klaas Vandepoele (VIB UGent) 

 

Title: “Unravelling transcription factor functions through integrative inference of transcriptional networks in plants”

Date : Thursday June 20th – 12h15

Location: Auditoire A – Génopode

 

Abstract of the talk:

Gene regulation is a dynamic process in which transcription factors (TFs) play an important role. While TF binding events can have a direct or indirect effect on the activation or repression of gene transcription, more complex regulation of gene expression is achieved through cooperative binding of different TFs adding an extra combinatorial level of complexity. Despite the functional importance of transcriptional regulation and the fact that >1700 TFs have been identified in the model species Arabidopsis thaliana, our global knowledge about the genes controlled by different TFs is limited. Recently, we have started to unravel the regulatory lexicon of Arabidopsis through the systematic processing of regulatory datasets comprising ChIP-Seq, protein-binding microarrays, chromatin modification data, RNA-Seq data and the delineation of conserved TF binding sites. Through the integration of different experimental and computational input networks using a supervised learning approach we constructed a gene regulatory network (GRN) covering 1,491 TFs and 31,393 target genes (1.7M interactions). We show that this integrated GRN (called iGRN) outperforms all input networks in terms of sensitivity and specificity to predict known regulatory interactions. iGRN has similar performance to recover known functional regulatory interactions compared to experimental methods like Y1H and ChIP. Through the analysis of the predicted target genes for different TFs, we are able to recover for >600 TFs known functions associated to specific biological processes such as growth, development, (a)biotic stress response, hormone signaling, circadian rhythm, etc. Furthermore, the iGRN allowed predicting new gene functions for >1000 TFs. I will present experimental validations for some new TFs predicted to be involved in oxidative stress signaling. In conclusion, the presented iGRN offers a high-quality starting point that integrates different functional omics data sets at the network level to enhance our understanding of gene regulation in plants.

 

To meet with Dr. Vandepoele during the day, please do register the following doodle 

 

No need to register to attend the talk – feel free to join and invite anybody who could be interested.

 

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Bruna DE QUEIROZ will give a seminar, 10:00am room 5022, in Genopode on June 18, 2019

SEMINAR

Bruna DE QUEIROZ

PhD candidate

Université de Bordeaux, France

Characterization of the miRNA content of astrocytic extracellular vesicles”

Tuesday June 18, 2019

At 10:00

Room 5022

Bâtiment Le Génopode
1015 Lausanne Dorigny

Host : Prof. David Gatfield

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Thesis defense of Judit CASTILLO ARMENGOL, June 24, 2019 – 4:30 pm in Aud. A, Génopode

Madame Judit CASTILLO ARMENGOL soutiendra en vue de l’obtention du grade de Doctorat ès sciences de la vie (PhD) de l’Université de Lausanne sa thèse intitulée “CDK4 as a novel regulator of brown adipose tissue biology”

Directeur de thèse : Monsieur le Professeur Lluis FAJAS COLL

Cette soutenance aura lieu le Lundi 24 juin 2019 à 16h30 dans l’Aud. A du Génopode.

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CIG Seminars Fall 2019 Program

CIG Seminars Fall 2019

Monday 12:15, Génopode, auditorium B, followed by sandwiches

Free entrance

Download the poster

Monday September 23, 2019
Vincent Prévot, University of Lille, France
«To be announced»
Hosts: PhD students & Postdocs

Monday September 30, 2019
Michael Hastings, MRC, Cambridge, UK
«Circadian clocks in the mammalian brain: genes, cells and circuits»
Host: Paul Franken

Monday October 21, 2019
Beat Fierz, EPFL, Lausanne, CH
«Gene control with a “twist”: Exploring the dynamic chromatin landscape»
Host: Maria C. Gambetta

Monday November 11, 2019
Arnaud Krebs, EMBL, Heidelberg, Germany
«Understanding principles of transcription regulation at the resolution of single DNA molecules»
Host: Maria C. Gambetta

Monday November 18, 2019
Anastasia Baryshnikova, Calico Life Sciences, San Francisco, USA
«Genome-wide phenotypic screens: the total greater than the sum of the parts»
Host: Jolanda van Leeuwen

Monday November 25, 2019
Kristin Tessmar-Raible, Max F. Perutz Laboratories, Vienna, Austria
«Timing physiology and behavior under the light of sun and moon»
Host: Richard Benton

Monday October 21, 2019
Matthias Lutolf, EPFL, Lausanne, CH
«How to reverse engineer an intestinal epithelium»
Host: Liliane Michalik