Anne would like to warmly thank Fabienne Junod Fontolliet for her superb work in the CIG Animalerie and precious critical life-saving assistance with her mouse colony!

 She also wishes to thank the SNSF for awarding her a Marie Heim-Vögtlin fellowship, and later Project subsidies allowing her to come to CH and generate these mouse models.

Science Translational Medicine 18 November 2015 Vol 7 Issue 314 314le2.

Abstract

Did hypocretin receptor 2 autoantibodies cause narcolepsy with hypocretin deficiency in Pandemrix-vaccinated children, as suggested by Ahmed et al.? Using newly developed mouse models to report and inactivate hypocretin receptor expression, Vassalli et al. now show that hypocretin neurons (whose loss causes narcolepsy) do not express hypocretin autoreceptors, raising questions to the interpretation of Ahmed et al.’s findings.