Fanny Cavat started working at the CIG, 5th floor for the groups of Prof. Wahli, Prof. Desvergne and Dr Michalik on April 15th, 2010 as a Lab Technician. She is leaving on December 31st, 2010.
Tag Archives: B.Desvergne
Annu Rev Physiol.: Group Desvergne
Annu Rev Physiol. 2010 Nov 5. [Epub ahead of print]
Endocrine Disruptors: From Endocrine to Metabolic Disruption.
Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, 1015 Switzerland.
Wed Nov 3, 2010 Seminar E.Mikò
“Differentially expressed microRNAs and the role of miR-126 in small cell lung cancer”
Wednesday November 3rd, 2010 12h00 – 13h00 Room 5022, 5th floor Genopode Building
Host : Prof. Béatrice Desvergne
Wed Oct 27, 2010 Seminar S.Kato GEN
Endocrinology; group Desvergne
Endocrinology. 2010 Sep 1. [Epub ahead of print]
PPAR{gamma} in Placental Angiogenesis.
Nadra K, Quignodon L, Sardella C, Joye E, Mucciolo A, Chrast R, Desvergne B.
Center for Integrative Genomics (K.N., L.Q., C.S., E.J., B.D.), University of Lausanne, CH-1015 Lausanne, Switzerland; and Department of Medical Genetics (K.N., R.C.) and Electron Microscopy Platform (A.M.), University of Lausanne, CH-1005 Lausanne, Switzerland.
Am J Respir Crit Care med; co-author: B. Desvergne
Am J Respir Crit Care Med. 2010 Aug 6. [Epub ahead of print]
Protective Role of Peroxisome Proliferator-Activated Receptor-{beta}/{delta} in Septic Shock.
Kapoor A, Shintani Y, Collino M, Osuchowski MF, Busch D, Patel NS, Sepodes B, Castiglia S, Fantozzi R, Bishop-Bailey D, Mota-Filipe H, Yaqoob MM, Suzuki K, Bahrami S, Desvergne B, Mitchell JA, Thiemermann C.
Centre for Translational Medicine & Therapeutics, William Harvey Research Institute, London, United Kingdom.
Abstract
RATIONALE: PPAR-beta/delta is a transcription factor that belongs to the PPAR nuclear hormone receptor family, but the role of PPAR-beta/delta in sepsis is unknown. OBJECTIVE: We investigated the role of PPAR-beta/delta in murine models of lipopolysaccharide (LPS)-induced organ injury/dysfunction and cecal ligation and puncture (CLP)-induced polymicrobial sepsis. METHODS: Wild-type (WT) and PPAR-beta/delta knockout (KO) mice, and C57BL/6 mice were subjected to LPS for 16 h. C57BL/6 mice received the PPAR-beta/delta agonist GW0742 (0.03 mg/kg intravenously, 1 h after LPS) or GW0742 plus the PPAR-beta/delta antagonist GSK0660 (0.1 mg/kg intravenously, 30 min before LPS). CD-1 mice subjected to CLP received GW0742 or GW0742 plus GSK0660. MEASUREMENTS AND MAIN RESULTS: In PPAR-beta/delta KO mice, endotoxemia exacerbated organ injury/dysfunction (cardiac, renal, hepatic) and inflammation (lung) when compared to WT-mice. In C57BL/6 mice subjected to endotoxemia, GW0742 significantly (i) attenuated organ (cardiac, renal) dysfunction and inflammation (lung), (ii) increased the phosphorylation of Akt and glycogen synthase kinase (GSK)-3beta, (iii) attenuated the decrease in extracellular signal-regulated kinase (ERK)1/2 and signal transducer and activator of transcription (STAT)-3 phosphorylation, and (iv) attenuated the activation of nuclear factor (NF)-kappaB and the expression of inducible nitric oxide synthase (iNOS). In CD-1 mice subjected to CLP, GW0742 improved 10-day survival. All the observed beneficial effects of GW0742 were attenuated by the PPAR-beta/delta antagonist GSK0660. CONCLUSIONS: PPAR-beta/delta protects against multiple organ injury/dysfunction and inflammation caused by endotoxic shock and improves survival in polymicrobial sepsis by a mechanism that may involve activation of the Akt and inhibition of GSK-3beta and NF-kappaB.