Welcome to Thomas!

Hello, my name is Thomas Arbogast and I have joined Prof. Alexandre Reymond’s lab as a postdoctoral researcher in March 2019.

After graduating in biochemistry, I worked in Dr. Yann Herault’s team during my PhD in genetics and neuroscience at the Institute of Genetics, Molecular and Cellular Biology (IGBMC) at the University of Strasbourg (France) from 2011 to 2015. I worked on the generation and characterization of mouse models for genetic syndromes caused by copy number variations (CNVs) including deletion and duplication for the 16p11.2 BP4-BP5 region which are associated with developmental delay and autism spectrum disorder, with a reciprocal effect on head circumference, brain structure, and body mass index.

Upon the completion of my PhD, I began in May 2015 my post-doctoral research at the Center for Human Disease Modeling (CHDM) leaded by Pr. Nicholas Katsanis at the Duke University. I used the zebrafish model to investigate the contribution of transcripts located within the 16p11.2 BP4-BP5 region to the puberty and cranio-facial phenotypes observed in 16p11.2 CNV carriers. I also generated and characterized KO mice candidate genes for head size symptoms including Kctd13 (located in the 16p11.2 BP4-BP5 region), and Lat (16p11.2 BP2-BP3 region).

At the CIG, my postdoctoral project will be to continue investigating mechanisms underlying rare genetic diseases using animal modeling.