CIG Seminars Fall 2024 program

Posted on by

Monday 12:15, Génopode, auditorium B

Monday September 23, 2024
Chloé Zubieta,
CNRS, Laboratoire de Physiologie Cellulaire et Végétale, Grenoble (FRA)
«Getting in phase- ELF3 phase transitions as a molecular mechanism of temperature sensing in Arabidopsis»
Host: Christian Fankhauser

Monday September 30, 2024
Alvaro Rada Iglesias,
University of Cantabria, Santander (ESP)
«Insulation of developmental loci: CTCF can not do it all»
Hosts: PhD Students and Postdocs

Monday October 28, 2024
Daan Noordermeer,
Université Paris-Saclay, Institute for Integrative Biology of the Cell, Gif-sur-Yvette (FRA)
«Decrypting genomic insulators in mammalian cells: control of inter-TAD loops through distinctly different mechanisms»
Hosts: Maria C. Gambetta & Nadine Vastenhouw

Monday November 11, 2024
Kiran Padmanabhan,
ENS Lyon (FRA)
«A clockless state: impact on chromatin and transcriptome landscapes»
Host: Paul Franken

Monday November 18, 2024
Annika Nichols,
University of Basel, Biozentrum (CH)
«TBA»
Host: Richard Benton

Thursday November 21, 2024 – CIG/DBMV seminar
Liam Dolan,
Gregor Mendel Institute of Molecular Plant Biology, Vienna (AUT)
«Light-modulated polarity development in Marchantia»
Host: Christian Fankhauser

Monday November 25, 2024
Antoine Peters,
Friedrich Miescher Institute, Basel (CH)
«TBA»
Host: Nadine Vastenhouw

Monday December 9, 2024
Tsutomu Suzuki,
University of Tokyo (Japan)
«Expanding world of tRNA modifications in health and disease»
Host: Jean-Yves Roignant

Monday December 16, 2024
Sophie Caron,
The University of Utah, Salt Lake City (USA)
«TBA»
Host: Richard Benton

PhD positions at Max Planck, deadline 17.10.2024

Posted on by

https://www.imprs-lm.mpg.de/index.php/join/apply

Applications to the IMPRS-LM PhD program are possible only via our ONLINE PORTAL.

The entire process, from opening of our application portal to the onsite interviews, unfolds over a four-month duration.
Applicants are initially granted a window of 6-8 weeks to register on our portal and complete their application.
Subsequently, our coordination office and the recruiting faculty will evaluate and select the top applicants that will be invited for a first interview online.

The online interviews will consist of two short online interactions: a panel interview & a scientific presentation.
Successful candidates will then be invited to an onsite visit 8 weeks later to meet the recruiting labs and find the best matching projects.

For more information, check the application FAQs or contact us.

WINTER SELECTION 2025

  • online registration and application*: starting on 5 September 2024
  • deadline for application: 17 October 2024
  • deadline for submission of reference letter: 23 October 2024 (24:00 German time)
  • online interviews: 4 – 6 December 2024
  • onsite visit: 3 -5 February 2025

RECRUITING GROUPS

Erdmann LAB
BIOCHEMISTRY / PROTEIN TARGETING / MOLECULAR CELL BIOLOGY / ORGANELLE BIOGENESIS


Kliza LAB
BIOCHEMISTRY / MOLECULAR BIOLOGY / PROTEOMICS / ADP-RIBOSYLATION


Meyer LAB
CELL BIOLOGY / MEMBRANE DYNAMICS / CHEMICAL AND GENETIC PERTURBATIONS / FLUORESCENCE MICROSCOPY


Musacchio LAB
BIOCHEMISTRY / BIOPHYSICS / CELL BIOLOGY / MOLECULAR BIOLOGY


Pfander LAB
CELL BIOLOGY / DNA REPLICATION / IN CELL RECONSTITUTION / GENETIC ENGINEERING


Saccá LAB
SYNTHETIC BIOLOGY / NANOMATERIALS AND SUPRAMOLECULAR CHEMISTRY / SPATIAL ORGANIZATION / DNA NANOTECHNOLOGY


Summerer LAB
SYNTHETIC BIOLOGY / EPIGENETICS and CHROMATIN / DIRECTED EVOLUTION / EPIGENOMICS TECHNOLOGIES


Tatzelt LAB
BIOCHEMISTRY / NEURODEGENERATIVE DISEASES / PROTEIN STRUCTURE AND FUNCTION / FLUORESCENCE MICROSCOPY


Trappmann LAB
BIOMATERIALS / TISSUE ENGINEERING / CELL-MATRIX INTERACTIONS / 3D CELL CULTURE


Westermann LAB
BIOCHEMISTRY / CELL BIOLOGY / CYTOSKELETON / CELL DIVISION: MITOSIS AND MEIOSIS


Winklhofer LAB
Project 1: CELL BIOLOGY / CELL SIGNALING / HOST PATHOGEN INTERACTIONS / LIVE CELL IMAGING
Project 2: BIOCHEMISTRY / NEURODEGENERATIVE DISEASES / PROTEOSTASIS / POST-TRANSLATIONAL MODIFICATIONS

NEXT SELECTION SUMMER 2025

  • online registration and application*: March-April 2025
  • online interviews: May 2025
  • onsite visit: June/July 2025

*By submitting your application to the IMPRS-LM database you allow us to store and process your data exclusively for the purpose of the recruitment process.
Please read here the Data Protection Statement of the IMPRS-LM.

Protein Sci, co-auth.:A.Stasiak

Posted on by

Theta-curves in proteins

Pawel Dabrowski-Tumanski 1, Dimos Goundaroulis 2 3, Andrzej Stasiak 4 5, Eric J Rawdon 6, Joanna I Sulkowska 7

. 2024 Sep;33(9):e5133.

  • PMID: 39167036
  • PMCID: PMC11337915 (available on 2025-08-21)
  • DOI: 10.1002/pro.5133

Abstract

We study and characterize the topology of connectivity circuits observed in natively folded protein structures whose coordinates are deposited in the Protein Data Bank (PDB). Polypeptide chains of some proteins naturally fold into unique knotted configurations. Another kind of nontrivial topology of polypeptide chains is observed when, in addition to covalent bonds connecting consecutive amino acids in polypeptide chains, one also considers disulfide and ionic bonds between non-consecutive amino acids. Bonds between non-consecutive amino acids introduce bifurcation points into connectivity circuits defined by bonds between consecutive and nonconsecutive amino acids in analyzed proteins. Circuits with bifurcation points can form θ-curves with various topologies. We catalog here the observed topologies of θ-curves passing through bridges between consecutive and non-consecutive amino acids in studied proteins.

iScience, co-auth.: group Fajas

Posted on by

BCL2L13 at endoplasmic reticulum-mitochondria contact sites regulates calcium homeostasis to maintain skeletal muscle function

Dogan Grepper 1, Cassandra Tabasso 1, Nadège Zanou 2, Axel K F Aguettaz 1 3, Mauricio Castro-Sepulveda 1, Dorian V Ziegler 4, Sylviane Lagarrigue 1, Yoan Arribat 1, Adrien Martinotti 1 3, Ammar Ebrahimi 1 3, Jean Daraspe 5, Lluis Fajas 4, Francesca Amati 1 3

. 2024 Jul 14;27(8):110510.

Abstract

The physical connection between mitochondria and endoplasmic reticulum (ER) is an essential signaling hub to ensure organelle and cellular functions. In skeletal muscle, ER-mitochondria calcium (Ca2+) signaling is crucial to maintain cellular homeostasis during physical activity. High expression of BCL2L13, a member of the BCL-2 family, was suggested as an adaptive response in endurance-trained human subjects. In adult zebrafish, we found that the loss of Bcl2l13 impairs skeletal muscle structure and function. Ca2+ signaling is altered in Bcl2l13 knockout animals and mitochondrial complexes activity is decreased. Organelle fractioning in mammalian cells shows BCL2L13 at mitochondria, ER, and mitochondria-associated membranes. ER-mitochondria contact sites number is not modified by BCL2L13 modulation, but knockdown of BCL2L13 in C2C12 cells changes cytosolic Ca2+ release and mitochondrial Ca2+ uptake. This suggests that BCL2L13 interaction with mitochondria and ER, and its role in Ca2+ signaling, contributes to proper skeletal muscle function.