Nature. co-auth.: group Reymond

Nature. 2012 Sep 6;489(7414):101-8. doi: 10.1038/nature11233.

Landscape of transcription in human cells.

Djebali SDavis CAMerkel ADobin ALassmann TMortazavi ATanzer ALagarde JLin WSchlesinger F,Xue CMarinov GKKhatun JWilliams BAZaleski CRozowsky JRöder MKokocinski FAbdelhamid RF,Alioto TAntoshechkin IBaer MTBar NSBatut PBell KBell IChakrabortty SChen XChrast JCurado J,Derrien TDrenkow JDumais EDumais JDuttagupta RFalconnet EFastuca MFejes-Toth KFerreira P,Foissac SFullwood MJGao HGonzalez DGordon AGunawardena HHowald CJha SJohnson R,Kapranov PKing BKingswood CLuo OJPark EPersaud KPreall JBRibeca PRisk BRobyr D,Sammeth MSchaffer LSee LHShahab ASkancke JSuzuki AMTakahashi HTilgner HTrout DWalters NWang HWrobel JYu YRuan XHayashizaki YHarrow JGerstein MHubbard TReymond A,Antonarakis SEHannon GGiddings MCRuan YWold BCarninci PGuigó RGingeras TR.


Centre for Genomic Regulation and UPF, Doctor Aiguader 88, Barcelona 08003, Catalonia, Spain.


Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell’s regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations, taken together, prompt a redefinition of the concept of a gene.



[PubMed – in process]