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joint-PhD position in Neuroscience available at the University of Turin (UNITO) and the University Côte d’Azur (UCA)

 A joint PhD position in Neuroscience is available at the University of Turin (UNITO) and the University Côte d’Azur (UCA) within the framework of the Vinci Program 2020 (Università Italo-Francese/Université Franco-Italienne). 

We are seeking for a highly motivated candidate, strongly interested in Experimental Neuroscience and Molecular Neurobiology and dedicated to high quality research. The research project deals with the identification of molecular mechanisms controlling mitochondrial function in postnatal neurogenic niches and their implication in cognitive disorders. 

The project will focus on the mitochondrial dysfunction caused by deficiency of the transcriptional regulator Nr2f1 (also known as COUP-TFI) and will address the downstream target genes crucial for mitochondrial function and investigate its outcome on neuronal plasticity and function. Patients with NR2F1 haploinsufficiency have mild to severe neurodevelopmental cognitive disorders, such as intellectual deficiency, epilepsy, learning and language impairments. The final goal is to unravel the cellular and molecular mechanisms by which Nr2f1 controls mitochondrial function in neurons and how this is correlated with proper cognitive behavior. 

The project will combine multiple methodologies ranging from gold-standard neuroanatomical approaches to advanced techniques, such as tissue clearing, light-sheet microscopy and 3D whole-brain reconstruction, and two-photon functional imaging, as well as genome-wide and in silico analyses and animal behavior. 

The successful candidate will enroll as a PhD student in Neuroscience at the University of Turin under the co-direction of Prof. Silvia De Marchis and Dr. Michèle Studer. The candidate needs to have good communication skills in English and willing to work in Italy and France since the project will be carried out in the “Adult Neurogenesis” group at the Neuroscience Institute Cavalieri Ottolenghi at UNITO and in the “Development and Function of Brain Circuits” group at UCA. 

The call will open on May 20, 2021 on the UNITO website (deadline for mid-June, 2021 – check the exact deadline on the platform) and the starting date of the PhD program is November 1st, 2021. The position is fully financed for four years. 

General information on the organization and activities of the PhD Program can be found on the PhD in Neuroscience website (https://dott-neuroscienze.campusnet.unito.it). 

If interested, please contact silvia.demarchis@unito and michele.studer@unice.fr by including an updated and detailed CV and a motivation letter

Relevant publications: 

Bonzano S, Crisci I, Podlesny-Drabiniok A, Rolando C, Krezel W, Studer M, De Marchis S. Neuron-Astroglia Cell Fate Decision in the Adult Mouse Hippocampal Neurogenic Niche Is Cell-Intrinsically Controlled by COUP-TFI In Vivo. Cell Rep. 2018 Jul 10;24(2):329-341. doi: 10.1016/j.celrep.2018.06.044. 

Flore G, Di Ruberto G, Parisot J, Sannino S, Russo F, Illingworth EA, Studer M, De Leonibus E. Gradient COUP-TFI Expression Is Required for Functional Organization of the Hippocampal Septo-Temporal Longitudinal Axis. Cereb Cortex. 2017 Feb 1;27(2):1629-1643. doi: 10.1093/cercor/bhv336. PMID: 26813976. 

Beckervordersandforth R. Mitochondrial Metabolism-Mediated Regulation of Adult Neurogenesis. Brain Plast. 2017 Nov 9;3(1):73-87. doi: 10.3233/BPL-170044. 

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PhD student position in RNA biology, circadian clocks and disease, CIG (UNIL)

>>>Link to the job add<<<

Introduction

The University of Lausanne (UNIL) hosts 14’100 students and nearly 3’800 collaborators, professors, and researchers. Ideally situated at the banks of Lake Geneva, near Lausanne’s city center, its campus brings together more than 120 nationalities and is embedded in the larger, regional, vibrant life science research cluster.

Presentation

To complement the research activities in the group of Prof. David Gatfield at the CIG (Center for Integrative Genomics) of the University of Lausanne, we are seeking to recruit a PhD student to work on projects relating to RNA biology, circadian clocks and disease.

Job information

Expected start date in position: 01.09.2021 or to be agreed
Contract length: 1 year, renewable, maximum 4 years
Activity rate: 100% (minimum of 50% for research thesis, maximum of 50% for the institute)
Workplace: University of Lausanne, Dorigny

Your responsibilities

The successful applicant’s main responsibility will consist in conducting scientific research within the broad topic of our lab, which investigates how regulatory mechanisms occurring at the RNA level interact with the circadian timekeeping system, including its relevance for disease. One of the envisioned projects will entail work with a novel in vivo model of nonsense mediated mRNA decay (NMD). The PhD student will benefit from exposure to a multidisciplinary mix of molecular biological, cellular and mouse genetics/behavioural approaches, in combination with state-of-the-art genomics (ribosome profiling) and bioinformatics techniques. Full funding for the position is available, although application to personal, international fellowship programs will be encouraged.

Your qualifications

Highly motivated scientist and critical thinker with a Master degree in biology, medicine, or a related discipline. Team player. Good knowledge in English (full working proficiency). Willingness and interest in developing a PhD thesis in the broader fields of chronobiology/molecular biology.

What the position offers you

The Gatfield lab is hosted at the Center for Integrative Genomics (CIG) at the University of Lausanne (UNIL), a vibrant, well-funded institute with a focus on functional genomics and equipped with modern core facilities (see www.unil.ch/cig). It is embedded in the broader Lausanne research environment that includes two universities (UNIL, EPFL), the Swiss Institute of Bioinformatics, Ludwig Center for Cancer Research, university hospital, and a cluster of biotech companies flourishing in the larger lake Geneva area. We offer a nice working place in a multicultural, diversified and dynamic academic environment.

Through the Gatfield lab’s membership in the National Centre of Competence in Research RNA & Disease (http://www.nccr-rna-and-disease.ch), lab members benefit from networking and training opportunities throughout Switzerland and contacts to other leading RNA research labs in Zürich, Bern, Basel and Geneva.

The PhD student will be enrolled in the Faculty of Biology and Medicine’s doctoral school (https://www.unil.ch/ecoledoctoralefbm/en/home.html).

Contact for further information

Prof. David Gatfield

Email: David.Gatfield@unil.ch
Phone number : +41 21 692 39 94
http://www.unil.ch/cig/gatfield

Your application

To apply, please submit a motivation letter describing why you are interested in joining our group, a CV (with copy of your Master grade), and contact details for 2 or more referees. Only applications through this website will be taken into account. We thank you for your understanding.

Deadline: 15.05.2021

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PhD and Postdoc opportunities to study genome architecture at the UNIZH, Zurich (CH)

Information on the Grob’s lab: https://www.botinst.uzh.ch/en/research/development/stefangrob.html

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Faculty positions open in molecular and cell biology, OIST, Okinawa (Japan)

Subject: Organoids and synthetic biology are areas of particular interest, but the scope of the search is quite broad.

Candidatures must be uploaded on the recruitment website by April 30, 2021: https://groups.oist.jp/facultypositions

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Post-doctoral position available in Conservation Biology, UNIBE, CH

Candidature must be sent to alexandre.depeyer@iee.unibe.ch by April 1st, 2021

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Post-doctoral fellow positions open in evolutionary cell biology, London (UK)

Post-doctoral fellow positions open to study the evolutionary divergence of lipid biosynthesis and membrane-associated functions in S. pombe and S. japonicus in the Oliferenko lab, King’s College London / Crick institute (UK).

Project:
1) probe the divergence of membrane homeostasis mechanisms (cell biology, genetics, various omics);
2) understand the functional impact of lipid repertoire on organismal physiology (lab evolution, retroengineering, physiology). 

Email: snezhana.oliferenko@kcl.ac.uk or snezhka.oliferenko@crick.ac.uk for further information.