ext. job openings Archive

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Lecturer position available in molecular genetics of yeasts, Univ. of Lyon (FR)

The recruited person will join the “Microbial Genetics” teaching team. She should have good knowledge general in microbiology and genetics. Deeper skills in yeast molecular genetics are essential in order to ensure specific lessons.

The research will be carried out within UMR5240 Microbiology Adaptation Pathogenesis, which develops research to decipher molecular mechanisms of adaptive processes in microorganisms. The recruited person will bring his skills to the “Signalling and Adaptive Mechanisms in Yeasts” (SMAL) team, which identified and characterized many elements involved in the detection and transmission of nutritional signals and particularly glucose in different yeast genera in recent years. His project will consist in elucidating the dynamics of networks interaction between the different factors of glucose signaling and their spatiotemporal coordination during the implementation instead of the adaptive response to carbon sources. These still poorly understood processes will be analyzed using multi-scale proteomics and interactomics approaches coupled with functional genetics and biology analyzes cellular. This project will be extended to models of pathogenic fungi in collaboration with the GFCP team of UMR5240 in order to promote the development of the transversal axis “Microbial interfaces: from structure to signaling” within the UMR5240. The transversality of the skills provided will be of great benefit to the rest of the unit. The candidate should have solid expertise in yeast genetics and cell biology and an excellent ability to team working. Skills in proteomics and/or interactomics will be highly appreciated.

Read the complete job description (in french): clic here

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Assistant Professor position available in Reproductive Medicine and Genome Editing, Deadline 22.02.2022

Assistant Professorship for Reproductive Medicine and Genome Editing

The Faculty of Medicine of the University of Zurich invites applications for an Assistant Professorship in Reproductive Medicine and Genome Editing, which will be integrated in the Department of Reproductive Endocrinology at the University Hospital Zurich. The successful candidate will be an embryologist or biologist with expertise in genome editing technologies, who aims to address fundamental or applied questions related to reproduction and genetic diseases. Scientists that develop resources and technologies to evaluate safety and efficiency of genome editing technologies in germ cells are in particular encouraged to apply.

A PhD and at least 2 years of postdoctoral experience with expertise in genome editing, and in stem cell biology or embryology are required. Expertise in the generation of genetically modified animals using CRISPR technology is of advantage. In accordance with Swiss legislation that does not permit research on genome editing in human germ line cells, expected research activities will focus on in vitro experiments in stem cells and in vivo studies in appropriate animal models. A strong publication track record related to the intended project is expected.

Particularly important for this position is a highly integrative personality, willingness to cooperate with the research partners and a sense for overarching goals.

The Professorship will be embedded within the University Research Priority Program (URPP) “Human Reproduction Reloaded”, which is an interdisciplinary research program evaluating causes and consequences of today’s reproductive medicine including a potential use of genome editing in human reproduction. The tasks of the professorship are focused on research, but also involve participation in teaching programs, research colloquia and the Executive Committee of the URPP. Due to the interdisciplinary design of the URPP, successful applicants are expected to engage in future cooperation with other members of the URPP working on ethical, legal, or societal aspects of genome editing. Potential research areas of interest include but are not limited to: development and assessment of novel genome editing technologies, their use for targeted therapy of genetic diseases, and the study of genetic interactions underlying human diseases. The research will be focused on germ cells.

After the end of the assistant professor period, the candidate will have the opportunity, given appropriate qualification, to continue as the head of basic research at the Department of Reproductive Endocrinology

The University of Zurich strives to increase the percentage of women in leading positions. Therefore, qualified female researchers are encouraged to apply.

Please submit your electronic application for this position by February 22nd, 2022 via Faculty Recruiting Tool.
Applications by mail or e-mail will not be considered. For additional information, please contact the President of the Search Committee, Prof. Dr. med. Daniel Konrad.

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A 80% lab technician position is available at the CIG, UNIL (CH)

>>> Link to the job offer <<<

Introduction

Institution d’enseignement et de recherche de premier plan au niveau international, l’UNIL compte près de 5’000 collaboratrices et collaborateurs et 17’000 étudiant·e·s, réparti·e·s entre le campus de Dorigny et les sites du CHUV et d’Epalinges. En tant qu’employeur, elle encourage l’excellence, la reconnaissance des personnes et la responsabilité.

www.unil.ch/carrieres

Présentation

Pour compléter son équipe, le Centre Intégratif de Génomique (CIG) est à la recherche d’un·e Technicien·ne de laboratoire à 80% dans le groupe du Dr Sophie Croizier. 

Le laboratoire Croizier travaille sur le rôle des molécules de guidage dans la formation des circuits hypothalamiques contrôlant le métabolisme énergétique et glucidique.

Pour plus de détails, veuillez consulter le site web du groupe : https://unil.ch/cig/home/menuinst/research/dr-sophie-croizier.html

Informations liées au poste

Entrée en fonction :01.03.2022 ou à convenir

Durée du contrat : 1 année

Taux d’activité : 80 %

Lieu de travail : Centre Intégratif de Génomique (CIG), Université de Lausanne, Dorigny.

Vos activités

Dans vos activités, vous serez amené·e à :

  • Prendre en charge des aspects techniques d’un projet de recherche lié à l’obésité et au diabète sous la supervision du responsable et en collaboration avec les autres membres du groupe de recherche.
  • Maintenir des cultures cellulaires et des lignées de souris.
  • Effectuer des expériences de laboratoire sous la supervision du responsable : expérimentation animale, culture cellulaire, biologie moléculaire, histologie et marquage de tissus, tests métaboliques sur animaux.
  • Restituer les résultats : tenir à jour le cahier de laboratoire et présenter les résultats en réunions de laboratoire.

Votre profil

Afin de compléter notre équipe, nous sommes à la recherche d’une personne avec le profil suivant :

  • Vous êtes titulaire d’un CFC de laborantin·e en biologie ou diplôme équivalent.
  • Vous travaillez de façon précise et faites preuve d’autonomie.
  • Vous avez une expérience dans le travail avec les rongeurs. Une expérience dans l’un ou plus des domaines suivants est un atout: biologie cellulaire et moléculaire, histologie
  • Vous collaborez facilement avec différents groupes de recherche.
  • Vous maîtrisez le français et avez de bonnes connaissances de l’anglais écrit et oral.
  • Vous maîtrisez les principaux outils informatiques et bureautiques, en particulier Powerpoint, Word et Excel.

Vos avantages

Un cadre de travail agréable dans un environnement académique multiculturel et diversifié.
Des possibilités de formation continue, une multitude d’activités et d’autres avantages à découvrir.

Davantage d’informations sur www.unil.ch/carrieres

Pour tout renseignement complémentaire

Dr Sophie Croizier
E-mail: sophie.croizier@unil.ch

Votre dossier de candidature

Délai de postulation :28.01.2022

Nous vous invitons à nous transmettre votre dossier complet en format Word ou PDF.
Il ne sera pris en compte que les candidatures adressées par le biais de ce site. 

Nous vous remercions de votre compréhension.

Cahier des charges du poste

Cliquez ici pour afficher le cahier des charges.

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Postdoc position available in Molecular mechanisms of RNA-binding protein dysfunction in neurodegenerative diseases, in IMB, Mainz (DE) – Deadline 31.01.22

 

Our lab investigates the molecular mechanisms of neurodegenerative diseases, most notably ALS (amyotrophic lateral sclerosis), FTD (frontotemporal dementia) and Alzheimer’s disease. We seek to unravel how certain RNA-binding proteins (RBPs), in particular TDP-43 and FUS, become mislocalized and aggregated in these disorders, and how dysregulation of these RBPs causes a decline in cell function and neurodegeneration. Our previous research demonstrated that RBP mislocalisation and aggregation in ALS and FTD are intimately linked to molecular defects in 1) nuclear import, 2) control of liquid-liquid phase separation (LLPS), and 3) post-translational modifications (PTMs). We therefore study how nuclear transport, phase separation and PTMs of these disease-linked RBPs are normally regulated, how they are misregulated in disease and how these pathological changes can possibly be reversed. 

In our research, we employ biochemistry, cell/molecular biology, imaging and biophysical techniques and use a combination of cellular models, reductionist in vitro reconstitution approaches and analysis of human post-mortem brains. 

For more information, visit our website: https://www.imb.de/research/our-research-groups/dormann/research 

 We offer 

• a highly collaborative research environment and cutting edge research facilities 
• opportunity to participate in the IMB Postdoc Programme (IPPro): IMB Mainz 
• an international, diverse and fun team 

Application deadline: January 31, 2022 

Please send your application containing a motivation letter, CV and reference letters or contact information of two referees to Dorothee Dormann (ddormann@uni-mainz.de). 

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Head of bioinformatics at the GTF, deadline: Feb 13, 2022

Link to the add

Presentation

The GTF head of bioinformatics is responsible for all data analysis and data management activities done by the platform. She•he functionally supervises the bioinformaticians team, analysis tools, and infrastructure to ensure that the facility delivers high quality data and that its users benefit from state-of-the-art genomics data processing procedures.

Job information

Expected start date: 01.03.2022
Contract length: Undetermined duration after a trial period
Activity rate: 80% or higher
Workplace: Lausanne Genopode (Dorigny)

Your responsibilities

In your functions, you will have to :

  • Manage the bioinformatics activities of the GTF
  • Be responsible for the GTF data management
  • Manage data analysis services carried out by the GTF
  • Ensure continuous improvement of the bioinformatic tools, methods, and services offered by the GTF.

Your qualifications

In order to complete our team, we are looking for someone with the following skills :

  • PhD related to Life Sciences domains (e.g. biology or bioinformatics)
  • Experience in several of the following topics: statistical analysis methods, bioinformatics, database management, programming
  • Advanced knowledge of next generation sequencing data analysis, in particular gene expression analysis
  • Experience in a production environment (e.g. industry) would be a plus.

What the position offers you

  • Nice working place in a multicultural, diverse and dynamic academic environment. Opportunities for professional training, a lot of activities and other benefits to discover.
  • Collaboration with many UNIL research departments, and involvement in a very large variety of scientific projects (from human genetics to ecology).
  • Access to the latest generation sequencers (short reads with the NovaSeq 6000 and long reads with the Pacific Biosciences Sequel II).

Contact for further information

Dr. Julien Marquis
julien.marquis.1@unil.ch

Your application

Deadline: 13.02.2022.

Please send your application as a single pdf file including:
•    Motivation letter,
•    Curriculum Vitae (with detailed dates),
•    Copy of university degrees certificates and transcripts of marks awarded,
•    Coordinates of two persons who can provide references.

Only applications through this website will be taken into account.

Job description

Click here to open the job description.

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PhD student position available in macronutrition and signaling regulated RNA metabolism, CIG, Lausanne (CH)

>>> clic here to see the job offer <<<

Introduction

UNIL is a leading international teaching and research institution, with over 5,000 employees and 17,000 students split between its Dorigny campus, CHUV and Epalinges. As an employer, UNIL encourages excellence, individual recognition and responsibility.

Presentation

Dr. Isabel Lopez-Mejia (https://www.unil.ch/cig/home/menuinst/research/dr-isabel-lopez-mejia.html) at the Center for Integrative Genomics at UNIL is seeking a PhD student with a strong background and interest in RNA processing, metabolism, physiology and molecular biology.

Job information

Expected start date in position : 01.01.2022 or to be agreed

Contract length : 1 year, renewable maximum 4 years

Activity rate : 100%

Workplace : University of Lausanne, Dorigny

Your responsibilities

The main research focus of our laboratory is to understand the participation of RNA processing in the regulation of energy metabolism in the context of obesity and diabetes.

The successful candidate will work on a project aiming to identify how external stimuli (nutrition, hormones, …) modulate RNA metabolism, in adipose tissue depots, to control whole body energy balance.

We study the molecular pathways connecting energy sensing and cell metabolism with the post-transcriptional control of gene expression. More specifically, we investigate the role of RNA binding proteins in white and brown adipose tissue function, and in the onset of insulin resistance and the metabolic syndrome.

Several aspects of RNA processing will be studied with a special focus on how signal-induced alternative splicing is altered in conditions of obesity and insulin resistance.

We use molecular and cellular biology approaches, as well as transcriptomic and proteomic tools to understand how macronutrition and external stimuli control RNA binding proteins in cellular models of adipocytes and mouse models of diet-induced obesity. For that purpose, we closely collaborate with the UNIL genomic technologies, protein analysis facilities and bioinformatics competence center located on site.

Although most of your time will be dedicated to you research project, you will also be involved in undergraduate teaching (e.g., practical class preparation, literature reading classes).

Your qualifications

  • A master’s degree in molecular biology, cell biology, physiology or a related topic.
  • Strong interests/skills in molecular biology, RNA processing, physiology, metabolism, bioinformatics.
  • Excellent scientific writing, communication and interpersonal skills, self-motivation and independence.
  • Experience in RNA splicing, cell metabolism and mouse physiology is a plus.

What the position offers you

You will be supervised by Dr. Isabel Lopez-Mejia in a multicultural, diverse and dynamic academic environment. The working language is English.

The Center for Integrative Genomics encompasses 15 research labs investigating diverse fields related to functional genomics and offers state-of-the-art experimental facilities. Beyond the training in the host laboratory, numerous possibilities exist at UNIL for further professional education (e.g., in bioinformatics, imaging, soft-skills, career development).

Contact for further information

Informal requests for information can be made by email to:
Isabel.LopezMejia@unil.ch

Your application

Deadline: 01.12.2021 – applications will be reviewed on a rolling basis until the position is filled.

To apply you must upload as a single pdf document:

  • A CV, including your grades, lists of publications, conferences, awards and a description of experimental skills.
  • The name and contact details of 2-3 referees.
  •  A motivation letter in English describing (i) your past research experience and (ii) your scientific interests, and how they are a good match for the host laboratory

Please, send your full application in Word or PDF.

Only applications through this website will be taken into account.
We thank you for your understanding.