Cell Metab. 2011 Oct 5;14(4):439-40.

Of Fat, β Cells, and Diabetes.

Thorens B.

Center for Integrative Genomics, Genopode Building, University of Lausanne,
CH-1015 Lausanne, Switzerland.

The molecular mechanisms linking diet, obesity, and type 2 diabetes are still
poorly understood. In a recent paper, Ohtsubo et al. (2011) show that high lipid 
levels induce nuclear exclusion of Foxa2 and HNF1α in β cells, leading to
impaired expression and glycosylation of proteins controlling glucose-stimulated 
insulin secretion.


PMID: 21982703  [PubMed - in process]