Clin Microbiol Infect; co-auth.: K.Harshman

Clin Microbiol Infect. 2014 Feb 25. doi: 10.1111/1469-0691.12609. [Epub ahead of print]

Genome-wide re-sequencing of multi-drug resistant Mycobacterium leprae Airaku-3.


Genotyping and molecular characterization of drug resistance mechanisms in Mycobacterium leprae enables disease transmission and drug resistance trends to be monitored. In the present study, we performed genome-wide analysis of Airaku-3, a multidrug resistant strain with an unknown mechanism of resistance to rifampicin. We identified 12 unique non-synonymous single-nucleotide polymorphisms (SNPs) including two in the transporter-encoding ctpC and ctpI genes. In addition, two SNPs were found that improve the resolution of SNP-based genotyping, particularly for Venezuelan and South-East Asian strains of M. leprae. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.


Mycobacterium leprae , Rifampicin-resistance, Single Nucleotide Polymorphism (SNP), leprosy, molecular epidemiology