Commun Biol.: auth.: D.Gatfield

Commun Biol. I(nsp1)ecting SARS-CoV-2-ribosome interactions

I(nsp1)ecting SARS-CoV-2-ribosome interactions

Matthieu Simeoni # 1Théo Cavinato # 1Daniel Rodriguez # 1David Gatfield 2Affiliations expand

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While SARS-CoV-2 is causing modern human history’s most serious health crisis and upending our way of life, clinical and basic research on the virus is advancing rapidly, leading to fascinating discoveries. Two studies have revealed how the viral virulence factor, nonstructural protein 1 (Nsp1), binds human ribosomes to inhibit host cell translation. Here, we examine the main conclusions on the molecular activity of Nsp1 and its role in suppressing innate immune responses. We discuss different scenarios potentially explaining how the viral RNA can bypass its own translation blockage and speculate on the suitability of Nsp1 as a therapeutic target.