Exploring the brain epitranscriptome: perspectives from the NSAS summit
Sung-Min Lee 1 2, Bonsang Koo 1 2, Clément Carré 3, André Fischer 4, Chuan He 5 6, Ajeet Kumar 1 2, Kathy Liu 7, Kate D Meyer 8 9, Guo-Li Ming 10 11 12 13, Junmin Peng 14 15, Jean-Yves Roignant 16 17, Erik Storkebaum 18, Shuying Sun 19, Davide De Pietri Tonelli 20, Yinsheng Wang 21, Yi-Lan Weng 22, Luigi Pulvirenti 23, Yanhong Shi 24, Ki-Jun Yoon 1 2, Hongjun Song 10 11 12 25
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Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neurodegeneration, and brain tumorigenesis, leading to the emergence of a new field termed neuroepitranscriptomics. Deficiency in machineries modulating RNA modifications has been implicated in a range of brain disorders from microcephaly, intellectual disability, seizures, and psychiatric disorders to brain cancers such as glioblastoma. The inaugural NSAS Challenge Workshop on Brain Epitranscriptomics hosted in Crans-Montana, Switzerland in 2023 assembled a group of experts from the field, to discuss the current state of the field and provide novel translational perspectives. A summary of the discussions at the workshop is presented here to simulate broader engagement from the general neuroscience field.