Front Neurosci. co-auth.: J-Y.Roignant

Exploring the brain epitranscriptome: perspectives from the NSAS summit

Sung-Min Lee 1 2Bonsang Koo 1 2Clément Carré 3André Fischer 4Chuan He 5 6Ajeet Kumar 1 2Kathy Liu 7Kate D Meyer 8 9Guo-Li Ming 10 11 12 13Junmin Peng 14 15Jean-Yves Roignant 16 17Erik Storkebaum 18Shuying Sun 19Davide De Pietri Tonelli 20Yinsheng Wang 21Yi-Lan Weng 22Luigi Pulvirenti 23Yanhong Shi 24Ki-Jun Yoon 1 2Hongjun Song 10 11 12 25

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Free PMC article


Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neurodegeneration, and brain tumorigenesis, leading to the emergence of a new field termed neuroepitranscriptomics. Deficiency in machineries modulating RNA modifications has been implicated in a range of brain disorders from microcephaly, intellectual disability, seizures, and psychiatric disorders to brain cancers such as glioblastoma. The inaugural NSAS Challenge Workshop on Brain Epitranscriptomics hosted in Crans-Montana, Switzerland in 2023 assembled a group of experts from the field, to discuss the current state of the field and provide novel translational perspectives. A summary of the discussions at the workshop is presented here to simulate broader engagement from the general neuroscience field.