Mol Cell.: auth.: group Roignant

Mol Cell. 2022 Jun 2;82(11):1979-1980. doi: 10.1016/j.molcel.2022.05.017.

Poly(m 6 A) tails stabilize transcripts

Guillaume Lavergne 1Jean-Yves Roignant 2Affiliations expand


Viegas et al. (2022) discover that in Trypanosoma brucei the poly(A) tails of the variant surface glycoprotein (VSG) transcripts are methylated, a mechanism that stabilizes these transcripts and ensures protection against the immune response in mammals.