Mol Cell. 2022 Jun 2;82(11):1979-1980. doi: 10.1016/j.molcel.2022.05.017.

Poly(m ⁶ A) tails stabilize transcripts

Guillaume Lavergne ¹, Jean-Yves Roignant ²Affiliations expand

Abstract

Viegas et al. (2022) discover that in Trypanosoma brucei the poly(A) tails of the variant surface glycoprotein (VSG) transcripts are methylated, a mechanism that stabilizes these transcripts and ensures protection against the immune response in mammals.

• PMID: 35659324
• DOI: 10.1016/j.molcel.2022.05.017