Nucleic Acids Res.: auth: group Dessimoz

Nucleic Acids Res. 2020 Nov 11;gkaa1007. doi: 10.1093/nar/gkaa1007. Online ahead of print.

OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and more

Adrian M Altenhoff 1 2Clément-Marie Train 3Kimberly J Gilbert 1 3 4Ishita Mediratta 3 5Tarcisio Mendes de Farias 1David Moi 1 3 4Yannis Nevers 1 3 4Hale-Seda Radoykova 6 7Victor Rossier 1 3 4Alex Warwick Vesztrocy 1 3 4Natasha M Glover 1 3 4Christophe Dessimoz 1 3 4 6 7
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OMA is an established resource to elucidate evolutionary relationships among genes from currently 2326 genomes covering all domains of life. OMA provides pairwise and groupwise orthologs, functional annotations, local and global gene order conservation (synteny) information, among many other functions. This update paper describes the reorganisation of the database into gene-, group- and genome-centric pages. Other new and improved features are detailed, such as reporting of the evolutionarily best conserved isoforms of alternatively spliced genes, the inferred local order of ancestral genes, phylogenetic profiling, better cross-references, fast genome mapping, semantic data sharing via RDF, as well as a special coronavirus OMA with 119 viruses from the Nidovirales order, including SARS-CoV-2, the agent of the COVID-19 pandemic. We conclude with improvements to the documentation of the resource through primers, tutorials and short videos. OMA is accessible at