Nucleic Acids Res; auth. I Xenarios

Nucleic Acids Res. 2012 Nov 17. [Epub ahead of print]

New and continuing developments at PROSITE.


SIB Swiss Institute of Bioinformatics, Centre Médical Universitaire (CMU), 1 rue Michel Servet, 1211 Geneva 4 and SIB Swiss Institute of Bioinformatics, Vital-IT Group, Quartier Sorge, Bâtiment Génopode, 1015 Lausanne, Switzerland.


PROSITE ( consists of documentation entries describing protein domains, families and functional sites, as well as associated patterns and profiles to identify them. It is complemented by ProRule a collection of rules, which increases the discriminatory power of these profiles and patterns by providing additional information about functionally and/or structurally critical amino acids. PROSITE signatures, together with ProRule, are used for the annotation of domains and features of UniProtKB/Swiss-Prot entries. Here, we describe recent developments that allow users to perform whole-proteome annotation as well as a number of filtering options that can be combined to perform powerful targeted searches for biological discovery. The latest version of PROSITE (release 20.85, of 30 August 2012) contains 1308 patterns, 1039 profiles and 1041 ProRules.