Nucleic Acids Res; co-auth.: I.Xenarios

Nucleic Acids Res. 2012 Nov 28. [Epub ahead of print]

ViralZone: recent updates to the virus knowledge resource.


SIB Swiss Institute of Bioinformatics, Swiss-Prot Group, Centre Médical Universitaire, CH-1211 Geneva 4, Switzerland, Translational Research Sciences, Hoffmann-La Roche Drug Discovery & Early Development, 340 Kingsland Street, Nutley, NJ 07110NJ, USA, Hoffmann La Roche, Bioinformatics and Exploratory Statistics Department, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland and SIB Swiss Institute of Bioinformatics, Vital-IT Group, Quartier Sorge-Bâtiment Génopode, 1015, Lausanne, Switzerland.


ViralZone ( is a knowledge repository that allows users to learn about viruses including their virion structure, replication cycle and host-virus interactions. The information is divided into viral fact sheets that describe virion shape, molecular biology and epidemiology for each viral genus, with links to the corresponding annotated proteomes of UniProtKB. Each viral genus page contains detailed illustrations, text and PubMed references. This new update provides a linked view of viral molecular biology through 133 new viral ontology pages that describe common steps of viral replication cycles shared by several viral genera. This viral cell-cycle ontology is also represented in UniProtKB in the form of annotated keywords. In this way, users can navigate from the description of a replication-cycle event, to the viral genus concerned, and the associated UniProtKB protein records.