Recent publications
0

Nat Commun.: co-auth.: L.Fajas

Nat Commun. 2021 Dec 2;12(1):7037. doi: 10.1038/s41467-021-27307-3.

The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes

Matthieu Lacroix # 1 2Laetitia K Linares # 1 2Natalia Rueda-Rincon 3Katarzyna Bloch 3Michela Di Michele 1 2Carlo De Blasio 1 2Caroline Fau 1 2Laurie Gayte 1 2Emilie Blanchet 1Aline Mairal 4Rita Derua 5Fernando Cardona 6Diane Beuzelin 4Jean-Sebastien Annicotte 7Nelly Pirot 1 8Adeline Torro 1Francisco J Tinahones 9Florence Bernex 1 8Justine Bertrand-Michel 4Dominique Langin 4 10Lluis Fajas 11Johannes V Swinnen 3Laurent Le Cam 12 13

Abstract

Growing evidence supports the importance of the p53 tumor suppressor in metabolism but the mechanisms underlying p53-mediated control of metabolism remain poorly understood. Here, we identify the multifunctional E4F1 protein as a key regulator of p53 metabolic functions in adipocytes. While E4F1 expression is upregulated during obesity, E4f1 inactivation in mouse adipose tissue results in a lean phenotype associated with insulin resistance and protection against induced obesity. Adipocytes lacking E4F1 activate a p53-dependent transcriptional program involved in lipid metabolism. The direct interaction between E4F1 and p53 and their co-recruitment to the Steaoryl-CoA Desaturase-1 locus play an important role to regulate monounsaturated fatty acids synthesis in adipocytes. Consistent with the role of this E4F1-p53-Steaoryl-CoA Desaturase-1 axis in adipocytes, p53 inactivation or diet complementation with oleate partly restore adiposity and improve insulin sensitivity in E4F1-deficient mice. Altogether, our findings identify a crosstalk between E4F1 and p53 in the control of lipid metabolism in adipocytes that is relevant to obesity and insulin resistance.

0

A postdoctoral position is available in bioinformatics at the CIG, UNIL (CH)

>>> Link to the job offer <<<

Introduction

The University of Lausanne Center of Integrative Genomics (CIG) is a vibrant, well-funded institute with a focus on functional genomics and equipped with modern core facilities (see www.unil.ch/cig). It is embedded in the broader Lausanne research environment that includes two universities (UNIL, EPFL), the Swiss Institute of Bioinformatics, the Vital-IT high-performance computing center, Ludwig Center for Cancer Research, university hospital, and a cluster of biotech companies flourishing in the larger Lake Geneva area.

Presentation

In our lab at the Center for Integrative Genomics (CIG) of the University of Lausanne, we aim to decipher gene expression regulatory mechanisms that act at the RNA level, combining both experimental and computational approaches. We are now seeking to recruit a bioinformatician (postdoctoral level; 80%) who will take a central role in strengthening the computational side of our projects related to the regulation of translation in mammals. The envisioned project entails the analysis, interpretation and modelling of ribosome profiling data, and in particular a variant of this technique that we have recently developed and that relies on the analysis of “disome footprints” (Arpat et al., Genome Research 2020).

Job information

Expected start date in position 01.01.2022 or to be agreed

Contract length : 1 year, renewable, maximum 5 years

Activity rate : 80%

Workplace : University of Lausanne, Dorigny

Your responsibilities

The successful candidate will closely collaborate with experimentalists involved in the project, while also benefitting from computational expertise in- and outside of the group. In particular, the Gatfield lab is part of the National Centre of Competence in Research RNA & Disease (http://www.nccr-rna-and-disease.ch), a Swiss research initiative to strengthen and coordinate its activities in the rapidly evolving area of RNA biology and to obtain a leading position in the translation of knowledge from basic research into medically useful applications. The successful candidate will benefit from NCCR networking and training opportunities throughout Switzerland and from contacts to other leading RNA research labs in Lausanne, Zürich, Bern, Basel and Geneva.

Your qualifications

The successful candidate should hold a PhD degree in a relevant discipline in the life sciences. He/she should demonstrate relevant qualifications and experience in computational biology, in particular experience in HTS data analysis, and have a good understanding and keen interest in biological questions; current knowledge of latest software and design standards; ability to define and solve logical problems for technical applications; knowledge of and ability to select, adapt and effectively use a variety of programming methods. We expect him/her to have excellent communication (English) and interpersonal skills.

What the position offers you

We offer a pleasant working place in a multicultural, diverse and dynamic academic environment. Opportunities for professional training, a lot of activities and other benefits to discover.

Contact for further information

Prof. David Gatfield
Email: David.Gatfield@unil.ch
Phone number: +41 21 692 39 94
http://www.unil.ch/cig/gatfield

Your application

To apply, please submit your motivation letter, CV (including degrees and list of scientific publications), and contact details for 2 or more referees.

Please, send your full application in Word or PDF.
Only applications through this website will be taken into account.
We thank you for your understanding.

Deadline : 10.12.2021
 

0

Congratulations to several Genopode (ex-)members on their participation in the Vortex race of 3km run!

On 43 teams running the Vortex race last Nov. 25th, the Génopode’s ones arrived 11th and 24th

Congratulation to the participants!

11th: Team les mardistes composed of Carlos L., Manuel B. and Gérard B.
24th: Team Jeyaly composed of Yann E., Lyam B. and Jean-Yves R.

All results can be found here: https://4bd5409b-b6db-46f8-b130-1f5610ea87d6.filesusr.com/ugd/bc83a2_e8dfd4e052fb4a07b2693932fad98ff4.pdf

Further information on the run: https://www.essul.ch/

0

Science Ethics at CIG, Thu. Jan. 27, 2022 at 1:00 PM in Aud. B

The « Science Ethics at CIG » which will take place on Thursday January 27, 2022 in Auditorium B, from 1pm to 5pm. It will be followed by an aperitif.

The course is expected to receive accreditation for half-day continuous education in animal experimentation.

As requested by CIG PIs, this seminar is compulsory for CIG members. Therefore, all scientists who have joined the CIG since March 2020 (i.e. after the occurrence of the previous course), must attend. Members of DBC are welcome!

Please register here using your unil email address: https://framadate.org/ZWbX2Q1sKf2wqJ5e

For further information, please contact Frédéric Preitner frederic.preinter@unil.ch

0

Movie Monday next week! Dec. 6, 2021 from 6:00 P.M

CIG and DBC members are invited to the screening of a great movie with great people after an exhausting day of work! If you are interested in the culture and languages of different countries, or you simply want to enjoy an afterwork beer and snacks 🍻, then we are pleased to invite you to the 2nd Monday Movie Night 🎬 #German

It will take place on the 6th of December at 18:00 in the 3rd floor meeting room (3027). 
We will screen the German movie “Der Baader-Meinhof Komplex” (TRAILER), which retells the story of the early years of the West German far-left terrorist organisation the Rote Armee Fraktion (Red Army Fraction, or Red Army Faction, a.k.a. RAF) from 1967 to 1977. The movie won and was nominated for numerous national and international awards, amongst them the Oscar and Golden Globe Award as the best Foreign Language Film of the Year 2009!! 😱
No panic, we will have English subtitles! ✌
To get an overview how many people are interested, please fill the doodle HERE.
We hope to see a lot of you there!

0

Slack space for CIG assistants

CIG PhDs and Postdocs have decided to create a CIG Slack space in an effort to improve between-the-floors dynamics and increase and ease the communication among them.

There are already channels for lunch and coffee breaks, PhD and PostDoc spaces, sports, social events etc. but feel free to suggest new ideas.

Please use your @unil.ch email and join us on: https://join.slack.com/t/cigmembers/shared_invite/zt-z5g70tcn-b1gILqodwG_9OAN8YcllLQ

The CIG representatives and CIG Social Committee members.