PhD Fellowship funded by the John James Memorial Foundation to fill 

The project is entitled ‘Charting the interface between metabolic states and gene regulation in heart disease’ and looks at how cells coordinate the interplay between metabolism and gene regulation. We investigate the novel concept of widespread interactions between major components of gene expression (RNA) and metabolism (Enzymes and Metabolites) to form coordinative REM networks [1, 2]. The PhD student will be based  at The John Curtin School of Medical Research at ANU, Canberra, Australia, and will participate in a collaborative project with MW Hentze at The European Molecular Biology Laboratory, Heidelberg, Germany, to tackle the relevance of REM networks in cardiac disease. Mass spectrometry will be employed to determine proteins in complex mixtures (proteomics). Similarly, next generation sequencing technology will be used to characterise gene regulation at the level of RNA. 

1. Hentze MW, Preiss T. Trends Biochem Sci. 2010;35:423-6. 2. Castello A…Preiss T…Hentze MW. Cell. 2012;149:1393-406.

More details can be found at http://www.nature.com/naturejobs/science/jobs/292616-PhD-on-the-interface-between-metabolic-states-and-gene-regulation-in-heart-disease

Applications should be sent to medical.gradprog@anu.edu.au, deadline is the 14th December.