- How do genes connect to their regulatory elements millions of base pairs away? We found that specific genes loop to distal loci dynamically during development. We study how these loops form and how they regulate
- How is regulatory cross talk prevented? We recently demonstrated that insulator proteins form physical and regulatory boundaries in the
fly genome. We now study the molecular mechanisms of
We use genetics (genomeengineering, screens), genomics (transcriptomics, chromatin accessibility, chromosome conformation
capture, genome-wide screens, single-cell genomics), imaging (fixed and live), and biochemistry (proteomics).
For more information: http://www.gambettalab.org
Expected start date: as soon as possible or as agreed
Contract length: 1 year, renewable 2 x 2 years (maximum 5 years)
You will work independently on one of two projects proposed. You will use multidisciplinary approaches in the fruitfly Drosophila. You will present your results during seminars with gene regulation research labs in Lausanne. You will get some exposure to teaching, supervising laboratory practicals for UNIL students (~2 weeks per year). Full funding for the
positions is available, but application to fellowships is also expected.
You are a dynamic and rigorous scientist with a PhD degree in Biology or a related discipline. You have experience in molecular biology, genetics, genomics, biochemistry or imaging. You are a critical thinker, a team player eager to participate in scientific discussions but able to work independently. You have a strong interest in developing your skills in multidisciplinary experimental strategies to understand basic mechanisms in gene regulation.
The Gambetta lab is hosted at the Center for Integrative Genomics (CIG) at the University of Lausanne (UNIL), a vibrant, well-funded institute with a focus on functional genomics and equipped with modern core facilities (see www.unil.ch/cig).