Physiology (Bethesda). 2010 Jun;25(3):176-85.
PPAR Modulation of Kinase-Linked Receptor Signaling in Physiology and Disease.
Center for Integrative Genomics, National Research Center “Frontiers in Genetics,” University of Lausanne, Lausanne, Switzerland.
Kinase-linked receptors and nuclear receptors connect external cues to gene transcription. Among nuclear receptors, peroxisome proliferator-activated receptors (PPARs) are of special interest in relation to widespread human diseases. Mapping out connections between PPARs and kinase-linked receptor signaling is central to better understand physiological and pathophysiological processes and to better define therapeutic strategies. This is the aim of the present review.