Semin Cell Dev Biol; auth.: F.Hamaratoglu

Semin Cell Dev Biol. 2014 May 9. pii: S1084-9521(14)00107-4. doi: 10.1016/j.semcdb.2014.04.036. [Epub ahead of print]

Dpp/BMP signaling in flies: From molecules to biology.


Decapentaplegic (Dpp), the fly homolog of the secreted mammalian BMP2/4 signaling molecules, is involved in almost all aspects of fly development. Dpp has critical functions at all developmental stages, from patterning of the eggshell to the determination of adult intestinal stem cell identity. Here, we focus on recent findings regarding the transcriptional regulatory logic of the pathway, on a new feedback regulator, Pentagone, and on Dpp’s roles in scaling and growth of the Drosophila wing.

Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.


Activating Element; Brinker; Dally; Daughters-against-dpp; Dpp; Drosophila; Feedback regulation; Growth; Morphogen; Optomotor-blind; Patterning; Pentagone; Scaling; Silencer Element; Spalt