Recent CIG publications Archive


Int J Mol Sci.: auth.: W.Wahli

 2019 Feb 14;20(4). pii: E812. doi: 10.3390/ijms20040812.

Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase.


Living organisms display internal biological rhythms, which are an evolutionarily conserved adaptation to the environment that drives their rhythmic behavioral and physiological activities. The gut microbiota has been proposed, in association with diet, to regulate the intestinal peripheral clock. However, the effect of gut dysbiosis on liver remains elusive, despite that germfree mice show alterations in liver metabolic functions and the hepatic daily rhythm. We analyzed whether the disruption of gut microbial populations with various antibiotics would differentially impact liver functions in mice. Our results support the notion of an impact on the hepatic biological rhythm by gram-positive bacteria. In addition, we provide evidence for differential roles of gut microbiota spectra in xenobiotic metabolism that could protect against the harmful pharmacological effects of drugs. Our results underscore a possible link between liver cell proliferation and gram-positive bacteria.


antibiotics; circadian rhythm; gene expression; gut microbiota; liver

PMID: 30769793



“Modeling the 3D Conformation of Genomes”, Chapter 6 written by the Stasiak group

In the book “Modeling the 3D Conformation of Genomes” published by CRC Press, the Chapter 6: “Introducing supercoiling into models of chromosome structure” was written by F. Benedetti, D. Racko, J. Dorier and A. Stasiak.

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FEBS Open Bio.: auth.: group Desvergne

 2019 Jan 18;9(2):328-334. doi: 10.1002/2211-5463.12579. eCollection 2019 Feb.

Renal mineralocorticoid receptor expression is reduced in lipoatrophy.


Obesity is a condition characterized by adipose tissue hypertrophy; it is estimated that the obesity epidemic accounted for 4 million deaths in 2015 and that 70% of these were due to cardiovascular disease (CVD). One of the mechanisms linking obesity to CVD is the ability of adipose tissue to secrete circulating factors. We hypothesized that adipose tissue and its secretory products may influence mineralocorticoid receptor (MR) expression. Here, we showed that expression of MR and its downstream targets (Cnksr3Scnn1b, and Sgk1) were significantly reduced in the kidneys of peroxisome proliferator-activated receptor-γ null (Pparg Δ/Δ ) and A-ZIP/F-1 (AZIPtg/+) lipoatrophic mice with respect to their controls. Intriguingly, MR expression was also found to be significantly reduced in the kidneys of genetically obese ob/ob mice. Our data suggest that adipose tissue contributes to the regulation of MR expression. Given that leptin deficiency seems to be the major feature shared by Pparg Δ/Δ , AZIPtg/+, and ob/ob mice, we speculate that adipose tissue modulates MR expression through the leptin system.


kidney; lipoatrophy; mineralocorticoid receptor; obesity

PMID: 30761257



PLoS Genet.: co-auth.: F.Schütz

 2019 Feb 8;15(2):e1007905. doi: 10.1371/journal.pgen.1007905. [Epub ahead of print]

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment.


RNA interference (RNAi) related pathways are essential for germline development and fertility in metazoa and can contribute to inter- and trans-generational inheritance. In the nematode Caenorhabditis elegans, environmental double-stranded RNA provided by feeding can lead to heritable changes in phenotype and gene expression. Notably, transmission efficiency differs between the male and female germline, yet the underlying mechanisms remain elusive. Here we use high-throughput sequencing of dissected gonads to quantify sex-specific endogenous piRNAs, miRNAs and siRNAs in the C. elegans germline and the somatic gonad. We identify genes with exceptionally high levels of secondary 22G RNAs that are associated with low mRNA expression, a signature compatible with silencing. We further demonstrate that contrary to the hermaphrodite germline, the male germline, but not male soma, is resistant to environmental RNAi triggers provided by feeding, in line with previous work. This sex-difference in silencing efficacy is associated with lower levels of gonadal RNAi amplification products. Moreover, this tissue- and sex-specific RNAi resistance is regulated by the germline, since mutant males with a feminized germline are RNAi sensitive. This study provides important sex- and tissue-specific expression data of miRNA, piRNA and siRNA as well as mechanistic insights into sex-differences of gene regulation in response to environmental cues.

PMID: 30735500



Oncotarget.: auth.: group Michalik

 2018 Dec 28;9(102):37614-37615. doi: 10.18632/oncotarget.26532. eCollection 2018 Dec 28.

The Janus face of rosiglitazone.


PPARγ; melanoma; rosiglitazone; tumor microenvironment

PMID: 30701018

Mol Psychiatry.: co-auth.: A.Reymond

 2019 Jan 31. doi: 10.1038/s41380-019-0358-8. [Epub ahead of print]

Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia.

Sønderby IE1Gústafsson Ó2Doan NT1Hibar DP3,4Martin-Brevet S5Abdellaoui A6,7Ames D8,9Amunts K10,11,12Andersson M13Armstrong NJ14Bernard M15Blackburn N16Blangero J16Boomsma DI17Bralten J18Brattbak HR19,20Brodaty H21Brouwer RM22Bülow R23Calhoun V24Caspers S10,11,12Cavalleri G25Chen CH26,27Cichon S28,29,30Ciufolini S31Corvin A32Crespo-Facorro B33,34Curran JE16Dale AM27Dalvie S35Dazzan P36,37de Geus EJC38,39de Zubicaray GI40de Zwarte SMC22Delanty N25,41den Braber A38,42Desrivières S43Donohoe G44,45Draganski B46,47Ehrlich S48,49,50Espeseth T1,51Fisher SE52,53Franke B18,53,54Frouin V55Fukunaga M56Gareau T55Glahn DC57,58Grabe H59Groenewold NA35Haavik J60Håberg A61Hashimoto R62Hehir-Kwa JY63Heinz A64Hillegers MHJ22,65Hoffmann P29,30,66Holleran L67Hottenga JJ6Hulshoff HE22Ikeda M68Jahanshad N3Jernigan T69Jockwitz C10,12,70Johansson S20,60Jonsdottir GA2Jönsson EG1,71Kahn R22Kaufmann T1Kelly S67Kikuchi M72Knowles EEM73Kolskår KK1,51,74Kwok JB75Hellard SL76,77Leu C78,79Liu J80,81Lundervold AJ60,82Lundervold A83Martin NG84Mather K85Mathias SR73McCormack M86,87McMahon KL88McRae A89Milaneschi Y90Moreau C91Morris D44,45Mothersill D67Mühleisen TW28,29Murray R92Nordvik JE74Nyberg L13Olde Loohuis LM93Ophoff R22,93Paus T94,95,96,97Pausova Z15Penninx B98Peralta JM16Pike B99Prieto C100Pudas S13,101Quinlan E102Quintana DS1,51Reinbold CS29,30Marques TR36,103Reymond A104Richard G1,51,74Rodriguez-Herreros B5,91Roiz-Santiañez R33,34Rokicki J1Rucker J37,43Sachdev P85Sanders AM1,51,75Sando SB61,105Schmaal L106,107,108Schofield PR109,110Schork AJ27Schumann G43Shin J15,93Shumskaya E18,53Sisodiya S111,112Steen VM76,77Stein DJ113,114Steinberg S2Strike L115Teumer A116Thalamuthu A85Tordesillas-Gutierrez D34,117Turner J118Ueland T1Uhlmann A35,119,120Ulfarsson MO2,121van ‘t Ent D6van der Meer D1van Haren NEM22Vaskinn A1Vassos E122Walters GB2,123Wang Y1Wen W85Whelan CD86Wittfeld K124Wright M84,125Yamamori H126Zayats T60,83Agartz I1Westlye LT1,51Jacquemont S91,127Djurovic S76,128Stefánsson H2Stefánsson K2,123Thompson P3Andreassen OA12916p11.2 European Consortium, for the ENIGMA-CNV working group.


Prior to and following the publication of this article the authors noted that the complete list of authors was not included in the main article and was only present in Supplementary Table 1. The author list in the original article has now been updated to include all authors, and Supplementary Table 1 has been removed. All other supplementary files have now been updated accordingly. Furthermore, in Table 1 of this Article, the replication cohort for the row Close relative in data set, n (%) was incorrect. All values have now been corrected to 0(0%). The publishers would like to apologise for this error and the inconvenience it may have caused.

PMID: 30705424