Welcome Manon Agostini !

Hello ! My name is Manon Agostini, and I am excited to join Pr. Gatfield’s team for a six-month internship, working on Lisa Bertrand’s project. My research will focus on the process of re-initiation and the involvement of specific factors in this mechanism.

I am originally from Paris. I first did my Bachelor’s degree in Health Biology at the University of Paris-Est Créteil. During this time, I completed an internship at the GLY-CRRET laboratory, studying the role of glycosaminoglycans in osteoarthritis. I then pursued the first year of my Master’s degree at the University of Paris-Saclay, specializing in Genetics, Cell Biology, and Molecular Biology. There, I had the opportunity to do an internship at the NeuroPSI laboratory, where I studied the circadian rhythms of Drosophila larvae.

Currently, I am in the second year of my Master’s program at Sorbonne University, specializing in RNA Genetics and Biochemistry. My goal is to further specialize in the regulation of genome expression by non-coding RNA. Outside of academics, I enjoy drawing, painting, and art in general, as well as hiking and discovering new places. I am thrilled to be part of this team and to contribute to this project. I look forward to meeting and collaborating with everyone !

Welcome Nicolas Gurtner !

Hello everyone,

My name is Nicolas Gurtner, and I’m excited to join Prof. Fajas’ lab as the new lab technician. I hold a Master’s degree in Medical Biology from UNIL and previously worked for a year as a staff scientist in Prof. Jean-Yves Chatton’s group at the Department of Fundamental Neurosciences.

I’m thrilled to be part of the CIG and look forward to collaborating with all of you !

Cancer Cell, co-auth.: M.Quadroni

Fibrotic response to anti-CSF-1R therapy potentiates glioblastoma recurrence

Spencer S Watson 1Anoek Zomer 2Nadine Fournier 3Joao Lourenco 3Manfredo Quadroni 4Agnieszka Chryplewicz 5Sina Nassiri 3Pauline Aubel 1Simona Avanthay 2Davide Croci 2Erik Abels 6Marike L D Broekman 6Douglas Hanahan 7Jason T Huse 8Roy T Daniel 9Monika E Hegi 10Krisztian Homicsko 11Giulia Cossu 12Andreas F Hottinger 13Johanna A Joyce 14

. 2024 Sep 9;42(9):1507-1527.e11.

 doi: 10.1016/j.ccell.2024.08.012.

Free article

Abstract

Glioblastoma recurrence is currently inevitable despite extensive standard-of-care treatment. In preclinical studies, an alternative strategy of targeting tumor-associated macrophages and microglia through CSF-1R inhibition was previously found to regress established tumors and significantly increase overall survival. However, recurrences developed in ∼50% of mice in long-term studies, which were consistently associated with fibrotic scars. This fibrotic response is observed following multiple anti-glioma therapies in different preclinical models herein and in patient recurrence samples. Multi-omics analyses of the post-treatment tumor microenvironment identified fibrotic areas as pro-tumor survival niches that encapsulated surviving glioma cells, promoted dormancy, and inhibited immune surveillance. The fibrotic treatment response was mediated by perivascular-derived fibroblast-like cells via activation by transforming growth factor β (TGF-β) signaling and neuroinflammation. Concordantly, combinatorial inhibition of these pathways inhibited treatment-associated fibrosis, and significantly improved survival in preclinical trials of anti-colony-stimulating factor-1 receptor (CSF-1R) therapy.

Bienvenue Aymeric Masson !!!

Hello everyone,

I’m Aymeric Masson, new postdoc in the group of Prof. Alexandre Reymond. I come from Clermont-Ferrand (France), where I did my bachelor’s degree in Life sciences followed by a master’s in Biology and Health with a final internship at iGReD (Institute of Genetics, Reproduction and Development) under the guidance of Dr C. Barrière. During these years, I developed a growing interest in genetics, epigenetics and the bioinformatic aspects that enable the study of these fields.

I moved to Dijon (France) for my PhD which I did in the Génétique des Anomalies du Développement laboratory (GAD) under the supervision of Dr A. Vitobello. During my PhD, I investigated the pathology of variants of uncertain significance mainly by generating transcriptomic data, setting up a chromosome conformation capture (Hi-C) protocol and building a basic skill set for analyzing both types of data. I am delighted to join the CIG to further explore how the genome functions, expresses itself, and the impact of its variations on health.

Aside from sciences and to share a bit about myself, I enjoy playing ice hockey for fun, listening to techno-inspired music (Vitalic, Worakls, Paul K, NTO, Contrefaçon…) and spending time with family and friends. I look forward to meeting and collaborating with all of you, see you around!