CIG in the media Archive

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Nat Commun.: auth.: group Benton

 2019 Feb 7;10(1):643. doi: 10.1038/s41467-019-08345-4.

Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system.

Abstract

Nervous systems exhibit myriad cell types, but understanding how this diversity arises is hampered by the difficulty to visualize and genetically-probe specific lineages, especially at early developmental stages prior to expression of unique molecular markers. Here, we use a genetic immortalization method to analyze the development of sensory neuron lineages in the Drosophila olfactory system, from their origin to terminal differentiation. We apply this approach to define a fate map of nearly all olfactory lineages and refine the model of temporal patterns of lineage divisions. Taking advantage of a selective marker for the lineage that gives rise to Or67d pheromone-sensing neurons and a genome-wide transcription factor RNAi screen, we identify the spatial and temporal requirements for Pointed, an ETS family member, in this developmental pathway. Transcriptomic analysis of wild-type and Pointed-depleted olfactory tissue reveals a universal requirement for this factor as a switch-like determinant of fates in these sensory lineages.

PMID: 30733440

 

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P.Franken was in “Science” (among others) on Thu. Jan. 24, 2019

Mice, like people, like to be rocked to sleep

Mild rocking helps both adults and children fall asleep faster and experience deeper, longer sleep. Scientists have suspected that the human vestibular system—the bits of the inner ear that keep us balanced and oriented in space—are involved, but there’s been no solid proof.

Link to the complete article: http://www.sciencemag.org/news/2019/01/mice-people-liked-be-rocked-sleep

 

Other press releases:

– “The guardian”https://www.theguardian.com/lifeandstyle/2019/jan/24/trouble-getting-sleep-need-get-into-swing-rocking-scientists
– “BBC news”https://www.bbc.com/news/health-46986419
–  “RTS info”: https://www.rts.ch/info/sciences-tech/10165792-le-bercement-ameliore-le-sommeil-et-la-memoire-chez-les-adultes.html
– “20 minutes”: https://test.20min.ch/ro/life/lifestyle/story/Se-faire-bercer-permet-de-mieux-dormir-12000767

 

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A.Stasiak’s publication was selected for editorials in “Physical Review Letters”, Sep. 18, 2018

Synopsis: Knotted Loops Fall Flat

A knotted loop of metal beads—mimicking a knotted molecule—organizes into a flat horizontal ring when drifting down through a viscous fluid.
Synopsis figure

P. Szymczak/University of Warsaw

“Long-chain molecules, like DNA, can develop knots, and these knots in turn affect how the molecules move through a liquid. To understand this behavior, researchers from Poland and Switzerland devised an experiment with loops of small metal beads dropped in a viscous fluid. To mimic the knotted molecular chains, the team arranged each loop to wind around itself in a loose knot. Surprisingly, all the loops settled into horizontally flat configurations as they fell—no matter how they were initially dropped. The results show a connection between topology and hydrodynamics that may help researchers understand the shape evolution of large molecules moving in fluids.

Previous studies of DNA knots have indicated that the speed at which a knotted DNA molecule drifts through a thick gel can be faster or slower depending on the complexity of its knot. Filming this motion directly for nanoscopic DNA would be nearly impossible, so the research team turned to macroscopic loops. The loops, which resemble small beaded bracelets, were formed with multiple loops that intertwined, to create loose, open knots, such as a trefoil knot and a figure-eight knot. The researchers dropped the loops one at a time into a tall cylinder filled with silicone oil. As they fell, the loops evolved from a random jumble of beads into a torus shape consisting of a flattened loop of intertwined strands (see video). These strands swirled around each other in a cyclic pattern. The team also performed numerical simulations and theoretically explained the flattening and swirling of the loops as a consequence of bead interactions mediated by the fluid. The work could provide insight into what happens when large molecules sediment inside a rapidly rotating centrifuge.”

– Michael Schirber
Michael Schirber is a Corresponding Editor for Physics based in Lyon, France.

 

Link to the publication: http://www.genomyx.ch/phys-rev-lett-co-auth-a-stasiak/ 

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The Franken group was in 24heures.ch, Aug. 10, 2018

MédecineLes chercheurs ont mis en lumière comment la privation de sommeil affecte les différents systèmes de l’organisme.

Les fonctions biologiques du sommeil sur l’organisme restent mal connues.

Les fonctions biologiques du sommeil sur l’organisme restent mal connues.

Fonction biologique essentielle de l’organisme, le sommeil reste mal connu. Des chercheurs de l’Université de Lausanne(UNIL) et de l’Institut suisse de bioinformatique (SIB) ont tenté sur la souris une nouvelle approche à large échelle.

Les scientifiques ont utilisé la méthode dite de la «génétique des systèmes», a indiqué vendredi l’UNIL dans un communiqué. Le but est de tirer des déductions sur certains phénomènes biologiques en liant de multiples niveaux d’information.

Les variations génomiques constituent le niveau principal, qui peut être complété par d’autres niveaux tels que les phénotypes – l’ensemble des traits observables d’un organisme -, ou encore le niveau d’expression des gènes et les métabolites.

«La génétique des systèmes permet d’avoir une vue globale et interconnectée de nombreux phénomènes», explique Paul Franken, professeur associé au Centre intégratif de génomique (CIG) de l’UNIL et directeur de cette étude publiée dans la revue PLOS Biology.

«Elle est par conséquent considérée comme une approche très prometteuse pour mieux prédire et comprendre certaines prédispositions à des maladies», poursuit le spécialiste, cité dans le communiqué.

Communiqué de pressehttps://news.unil.ch/display/1533718551251 
Publicationhttp://www.genomyx.ch/plos-biol-auth-group-franken-and-i-xenarios/ 

24heures.chhttps://www.24heures.ch/suisse/Des-chercheurs-de-l-UNIL-decryptent-le-sommeil–/story/11055989

Tribunedegeneve.chhttps://www.tdg.ch/news/news/chercheurs-unil-decryptent-sommeil/story/11055989

LeMatin.chhttps://www.lematin.ch/suisse/Des-chercheurs-de-l-UNIL-decryptent-le-sommeil–/story/11055989

L’information a également été reprise dans les médias suivants: 20minutes.ch; Swissinfo.ch; Radio Fréquence Jura; Radio NeuchâteloiseRadio Jura BernoisLa Liberté; Le Courrier; ATS; SDA

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C.Dessimoz was on “WE Demain”, July 19, 2018

Par Claire Commissaire I Publié le 19 Juillet 2018

De plus en plus d’entreprises proposent aux particuliers de tester leur ADN pour connaître pêle-mêle, leurs origines géographiques ou retrouver des parents éloignés. Mais communiquer ces données sensibles est-il vraiment sans risque ?

Article complet: https://www.wedemain.fr/Votre-ADN-peut-il-etre-hacke_a3411.html

Crédits : Shutterstock
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N.Hernandez was in “Premier rendez-vous” on RTS 1, on Aug. 21, 2018

«Pour la première fois, Philippe Soltermann rencontre Nouria Hernandez», une émission de Pauline Vrolixs.

Nouria Hernandez, Rectrice de l’UNIL et professeure ordinaire à la FBM au sein du Centre intégratif de génomique, était l’invitée de  l’émission “Premier rendez-vous” sur la RTS1 : https://www.rts.ch/play/radio/premier-rendez-vous/audio/pour-la-premiere-fois-philippe-soltermann-rencontre-nouria-hernandez?id=9760651&station=a9e7621504c6959e35c3ecbe7f6bed0446cdf8da