Recent publications
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FREG sponsorship for PhD students

PhD students at the CIG can apply to the FREG funds (Fund for Research and Education in Genetics) which sponsors their participation to either an international conference or course during their thesis. (up to CHF 2’500,-).

To apply, email Nathalie Clerc and CC your PI, specifying the name of the course/meeting, its date and what you will present.

 

After the meeting/course the grantee will need to write a short report in the form of a letter to the Grace family describing the benefits for him/her attending the meeting/course (a template will be provided).

 

 

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Genes Dev.: auth.: group Hernandez

Genes Dev. 2017 Mar 13. doi: 10.1101/gad.293324.116. [Epub ahead of print]

Transcriptional interference by RNA polymerase III affects expression of the Polr3e gene.

Abstract

Overlapping gene arrangements can potentially contribute to gene expression regulation. A mammalian interspersed repeat (MIR) nested in antisense orientation within the first intron of the Polr3e gene, encoding an RNA polymerase III (Pol III) subunit, is conserved in mammals and highly occupied by Pol III. Using a fluorescence assay, CRISPR/Cas9-mediated deletion of the MIR in mouse embryonic stem cells, and chromatin immunoprecipitation assays, we show that the MIR affects Polr3e expression through transcriptional interference. Our study reveals a mechanism by which a Pol II gene can be regulated at the transcription elongation level by transcription of an embedded antisense Pol III gene.

KEYWORDS:

Polr3e gene; RNA polymerase; SINE; antisense transcription; gene expression regulation; transcriptional interference

PMID: 28289142
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DEE mini-symposium, March 23 & 24, 2017

Minisymposium_DEE_poste_rang_prof

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Mon March 20, 2017 CIG Sem. L. Giorgetti

CIG Seminars Spring 2017

Monday 12:15, Génopode, auditorium B, followed by sandwiches

Download the poster

Monday March 20, 2017
Luca Giorgetti, Friedrich Miescher Institute for Biomedical Research, Basel, CH
«A quantitative analysis of the hierarchical folding of mammalian genomes»
Hosts: Vincent Dion & Andrzej Stasiak

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Congratulations to Shanaz Diessler for her award of the best thesis in neuroscience!

Dr Shanaz Diessler (Franken lab) will be awarded the Biaggi de Blasys prize for the best thesis in neuroscience in the Lemanic network in 2016.

This is the third of these awards for Franken’s group after Ralf Wimmer in 2012, and Géraldine Mang in 2015.

The award ceremony will take place during the Brain Awareness Week events at the CHUV Lausanne on March 16, 2017.

 

Programme: http://www.unil.ch/files/live/sites/ln/files/shared/SdC/SdC2017_Lausanne.pdf

Further information on : www.lasemaineducerveau.ch

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Curr Opin Insect Sci.: auth.: R. Benton


Highlights

Insect disease vectors display diverse feeding preferences and regimes.

Taste organs and receptors exhibit species-specific variations on common themes.

Gustatory behaviors are plastic through reproductive cycles, experience and evolution.

Some insect repellents act by modulating feeding behaviors.


For insect vectors of human diseases, mealtimes are a key moment of infection. Understanding how and when such species decide on what to feed is both an interesting problem in sensory neurobiology and a source of information for intervention of these behaviors to control spread of infectious agents. Here I review the current knowledge of the molecular and cellular mechanisms of gustation in insect disease vectors, covering blood-feeders as well as scavengers that spread pathogens indirectly. I also consider how these behaviors are modulated over short and long timescales, and describe efforts to artificially modulate them. Though a relatively nascent field, gustatory neurobiology in insect vectors has much promise for future fundamental discoveries and practical applications.