Recent publications
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Cover of Genome Research: group Reymond

Per aspera ad astra. Two men are climbing up the tree of life, representing two different genomes that are expressing themselves starting from the level of double helix (trunk), nucleosomes (fruits), and chromatin (leaves). The tree crown is growing up toward the cosmos, toward an unknown future. The climbing is much more difficult for the man on the left since he carries a heavy backpack—representing a severe mutation, such as trisomy 21 in Down syndrome individuals. However, both have progressed above the clouds, which represent natural embryonic selection. In this issue, a study suggests that only a highly fit climber (i.e., with a deficit of slightly deleterious variants) is able to climb successfully with a backpack. (Cover illustration is a watercolor painting by Viktoria Polomoshnova, a student of the Immanuel Kant Baltic Federal University, Russia. [For details, see Popadin et al., pp. 1–10.])

 

Link to the article: http://genome.cshlp.org/content/28/1/1.abstract

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A.Reymond was in “20 minutes”, January 4, 2018

Une maladie très rare découverte à Lausanne

Des scientifiques lausannois et lituaniens ont mis au jour une affection très sévère qui touche certains enfants. Leur découverte a été financée avec le premier milliard de cohésion.

Des chercheurs ont découvert une maladie génétique extrêmement rare. Les travaux sont le fruit d’un projet associant l’Université de Lausanne et la Lituanie dans le cadre du premier fonds de soutien de la Suisse aux pays de l’Est devenus membres de l’UE.
L’étude a porté sur une maladie qui débouche sur une malformation cérébrale sévère. L’enfant ne parle pas, ne marche pas, ou souffre par exemple de raideur articulaire. Dans le pire des cas, le foetus ou le nouveau-né ne survit pas, explique jeudi l’Université de Lausanne (UNIL).

Article complet: http://m.20min.ch/ro/news/vaud/story/13886335 
Article dans 24 heures: https://www.24heures.ch/vaud-regions/maladie-rare-decouverte-unil-lituanie/story/24379739 
Article dans La Cote: https://www.lacote.ch/articles/regions/vaud/decouverte-d-une-maladie-tres-rare-726665 
Article dans Le Temps: https://www.letemps.ch/sciences/2018/01/04/une-nouvelle-maladie-genetique-rare-decouverte-luniversite-lausanne
Lien vers la publication: http://www.cell.com/ajhg/abstract/S0002-9297%2817%2930491-3

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Interviews of the CIG PIs: L.Fajas

Series of interviews were written to present each PI of the CIG.
Most of them are already available on the new CIG Report’s website, and every week we will be displaying one of them in the newsletter.

“Marriage de raison?”

The interplay between cell cycle control and metabolism

Prof. Lluis Fajas Coll and his team are walking along a hitherto deserted research path, unraveling the complex interplay between cell cycle regulation and metabolism – two phenomena that have been, for too long now, scientifically approached as independent, without biologically relevant interaction. But in recent years, the minds of not a few researchers have been turned. And not without reason: understanding the mutual interplay between cell cycle regulators and metabolic processes under normal and pathological conditions sheds new light on the understanding of metabolic diseases.

„Two roads diverged in a wood and I – I took the one less travelled by, and that has made all the difference.“

Robert Frost (1874 – 1963)

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Washing facility – use of the glassware

We remind you that glassware stocked at the washing facility is reserved for the washing facility only.
Please, do not help yourselves.
If you need glassware, contact Joan Justiniano (39.54)

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Front Endocrinol (Lausanne).: auth.: group Fajas

Front Endocrinol (Lausanne). 2017 Dec 21;8:362. doi: 10.3389/fendo.2017.00362. eCollection 2017.

Editorial: Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions.

KEYWORDS:

N-acetylaspartate; Warburg effect; cancer metabolism; cell cycle proteins; epigenetic modifications; macropinocytosis; mitochondrial diseases; tumor microenvironment

PMID: 29312151

 

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Dev Cell.: auth.: group Gatfield

Dev Cell. 2018 Jan 8;44(1):7-9. doi: 10.1016/j.devcel.2017.12.018. Epub 2018 Jan 8.

Circadian Clocks and UPR: New Twists as the Story Unfolds.

Abstract

Circadian clocks help control the unfolded protein response (UPR). In a recent issue of Nature Cell Biology, Bu et al. (2017) show that the interaction is reciprocal, with miRNA-211 providing a signal from the UPR to the clock component BMAL1, affecting circadian timing, global translational control, and cancer cell survival.

PMID: 29316442