Recent publications
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Behav Brain Res.: co-auth.: group Reymond

Behav Brain Res. 2017 Apr 11. pii: S0166-4328(17)30113-4. doi: 10.1016/j.bbr.2017.04.014. [Epub ahead of print]

Behavioural characterization of AnkyrinG deficient mice, a model for ANK3 related disorders.

Abstract

ANK3 encodes AnkyrinG (AnkG), a member of the Ankyrin family that is expressed in several different isoforms in many tissues. A unique serine-rich domain and tail domain in the two largest isoforms of AnkG (270 and 480kDa), restrict AnkG to the axon initial segment and nodes of Ranvier of myelinated neurons. At these sites, AnkG is a master regulator, coordinating the strict clustering of components necessary for proper action potential initiation and propagation along the axon. These components include voltage-gated sodium channels, potassium channels and members of the L1 cell adhesion molecule family. Genetic variation in the ANK3 gene has been linked to a range of neuropsychiatric and neurodevelopmental disorders in human, including schizophrenia, bipolar disorder, intellectual disability and autism spectrum disorders. Here, we study the effect of reduced expression of the large isoforms of Ank3 on cognition and behaviour using a heterozygous knockout mouse model. In three independent behavioural tests, being the open field test, elevated plus maze and social interaction test, we found evidence for increased anxiety in our Ank3 mouse model. Besides, we observed specific neuroanatomical defects in heterozygous knockout mice, including a smaller cingulate cortex, granular retrosplenial cortex, primary motor cortex and fimbria of the hippocampus.

KEYWORDS:

Ank3; AnkyrinG; Behavioural testing; Mouse model; Neurodevelopmental disorders

PMID: 28411148
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LIMNA Symposium: Metabolism research in Switzerland, June 01, 2017 – EPFL

Poster LIMNA

Poster

Programme

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Sci Rep.: co-auth.: group Benton

Sci Rep. 2017 Apr 7;7(1):719. doi: 10.1038/s41598-017-00350-1.

The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes.

Abstract

Chemical and mechanical cues from the cerebrospinal fluid (CSF) can affect the development and function of the central nervous system (CNS). How such cues are detected and relayed to the CNS remains elusive. Cerebrospinal fluid-contacting neurons (CSF-cNs) situated at the interface between the CSF and the CNS are ideally located to convey such information to local networks. In the spinal cord, these GABAergic neurons expressing the PKD2L1 channel extend an apical extension into the CSF and an ascending axon in the spinal cord. In zebrafish and mouse spinal CSF-cNs originate from two distinct progenitor domains characterized by distinct cascades of transcription factors. Here we ask whether these neurons with different developmental origins differentiate into cells types with different functional properties. We show in zebrafish larva that the expression of specific markers, the morphology of the apical extension and axonal projections, as well as the neuronal targets contacted by CSF-cN axons, distinguish the two CSF-cN subtypes. Altogether our study demonstrates that the developmental origins of spinal CSF-cNs give rise to two distinct functional populations of sensory neurons. This work opens novel avenues to understand how these subtypes may carry distinct functions related to development of the spinal cord, locomotion and posture.

PMID: 28389647
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Welcome to Carlos!

Welcome to Carlos Luzolo Soba,  who joined the stock and ordering service at the CIG. He is experienced in stock management and safety in a biomedical environment. He has two kids and is keen on running. 

verbier

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CIG FAQ: update of the building cleaning schedule for 2017

The cleaning and waste disposal page of the CIG FAQ was updated with new information related to the cleaning:

https://www.unil.ch/cig/home/menuguid/faq/cleaning-and-waste-disposal.html 

Updated document: http://unil.ch/cig/files/live/sites/cig/files/FAQ/nettoyage/Planning_nettoyage_CIG_2017.pdf

 

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PhD student position available in Trinity College, Dublin – deadline 20.05.2017

A PhD position is available in the research group of Aoife McLysaght in Trinity College Dublin to work on comparative genomics of vertebrates with a focus on understanding dosage sensitive genes in terms of evolution and disease. The execution of the project will involve bioinformatics and computer programming as well as statistical analysis of data.

For examples of the kinds of things we work on, look up our papers on PubMed:
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=mclysaght+a[au]&dispmax=50

Applicants should be in the final year of, or hold, a bachelor’s degree in molecular biology with an interest and aptitude for programming and bioinformatics; or vice versa (computer science bachelor’s with an interest in molecular biology). Interest and enthusiasm for molecular evolution is essential.

Students will be expected to be self-motivated and creative and to work closely with other members of the team.

This is a four-year position and comes with a tax-free stipend of 18000euro and covers fees up to EU level (non-EU students may apply, but fees are only covered up to EU rates).

TCD is Ireland’s top ranked University and a member of the League of European Research Universities (LERU). The McLysaght lab is funded by a European Research Council (ERC) Starting Grant. Lab: http://www.gen.tcd.ie/molevol/

Applications including a cover letter, CV, summary of scientific interests and reasons for being interested in our research group, and contact details for two referees should be made to
aoife.mclysaght@tcd.ie. Deadline for application is May 20th 2017. Informal discussions prior to applications are very welcome.

 

PhD_McLysaghtLab