Recent publications
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Dr. Klaas Vandepoele will give a seminar – 12:15 p.m. in Aud. A Génopode, on June 20, 2019

DBC seminar

Dr. Klaas Vandepoele, from the VIB-UGent Center for Plant Systems Biology on June 20th, at 12h15

More about Klaas Vandepoele (VIB UGent) 

 

Title: “Unravelling transcription factor functions through integrative inference of transcriptional networks in plants”

Date : Thursday June 20th – 12h15

Location: Auditoire A – Génopode

 

Abstract of the talk:

Gene regulation is a dynamic process in which transcription factors (TFs) play an important role. While TF binding events can have a direct or indirect effect on the activation or repression of gene transcription, more complex regulation of gene expression is achieved through cooperative binding of different TFs adding an extra combinatorial level of complexity. Despite the functional importance of transcriptional regulation and the fact that >1700 TFs have been identified in the model species Arabidopsis thaliana, our global knowledge about the genes controlled by different TFs is limited. Recently, we have started to unravel the regulatory lexicon of Arabidopsis through the systematic processing of regulatory datasets comprising ChIP-Seq, protein-binding microarrays, chromatin modification data, RNA-Seq data and the delineation of conserved TF binding sites. Through the integration of different experimental and computational input networks using a supervised learning approach we constructed a gene regulatory network (GRN) covering 1,491 TFs and 31,393 target genes (1.7M interactions). We show that this integrated GRN (called iGRN) outperforms all input networks in terms of sensitivity and specificity to predict known regulatory interactions. iGRN has similar performance to recover known functional regulatory interactions compared to experimental methods like Y1H and ChIP. Through the analysis of the predicted target genes for different TFs, we are able to recover for >600 TFs known functions associated to specific biological processes such as growth, development, (a)biotic stress response, hormone signaling, circadian rhythm, etc. Furthermore, the iGRN allowed predicting new gene functions for >1000 TFs. I will present experimental validations for some new TFs predicted to be involved in oxidative stress signaling. In conclusion, the presented iGRN offers a high-quality starting point that integrates different functional omics data sets at the network level to enhance our understanding of gene regulation in plants.

 

To meet with Dr. Vandepoele during the day, please do register the following doodle 

 

No need to register to attend the talk – feel free to join and invite anybody who could be interested.

 

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Bruna DE QUEIROZ will give a seminar, 10:00am room 5022, in Genopode on June 18, 2019

SEMINAR

Bruna DE QUEIROZ

PhD candidate

Université de Bordeaux, France

Characterization of the miRNA content of astrocytic extracellular vesicles”

Tuesday June 18, 2019

At 10:00

Room 5022

Bâtiment Le Génopode
1015 Lausanne Dorigny

Host : Prof. David Gatfield

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Tenure track assistant professor positions available in RNA biosciences at the University of Michigan

Multiple Faculty Positions Open in RNA Biosciences

The Center for RNA Biomedicine, recently becoming a pioneering part of the $150M University of Michigan Biosciences Initiative, solicits applications for faculty positions at the assistant professor level. The faculty positions will be on the tenure track with university year appointments starting Sep. 1, 2020, or Jan. 1, 2021.

Candidates must have the following qualifications:
• A PhD, MD, or other terminal degree
• Evidence of superlative scientific accomplishment and scholarly promise
• Depending on field, evidence of teaching excellence

Primary school and departmental affiliation(s) will be determined by the applicant’s qualifications and preferences, and by relevance of the applicant’s research program to departmental initiatives and themes. We welcome applications from outstanding scientists in any area of RNA research complementary to existing expertise at Michigan, with particular emphasis on RNA drug targeting or as medicine, structural biology of RNA nanomachines, RNA structural in vivo profiling, RNA protein interaction profiling, and in vivo analysis of long non-coding RNA function. For further information about the Center for RNA Biomedicine’s current research areas, please visit umichrna.org.

All applications must be submitted online at rna.lsa.umich.edu/facRecruiting/. You will be asked to upload the following materials: a cover letter, a curriculum vitae, a brief summary of recent research accomplishments and statement of future research plans, and a statement of teaching interests and philosophy. Candidates should also provide names and contact information for at least three references, as instructed in the online application form. To ensure full consideration, all materials should be received by Sep. 15, 2019.

Women and underrepresented minorities are encouraged to apply. The University of Michigan is supportive of the needs of dual career couples and is an equal opportunity/affirmative action employer.

For more information, contact us directly at mjerant@umich.edu or 734-615-8213

Learn more about the Biosciences Initiative at University of Michigan: biosciences.umich.edu

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Congratulations to A. Reymond on his election as President of the European Society of the Human Genetics, June 2019

Alexandre Reymond élu Président de la Société européenne de génétique humaine

Directeur du Centre intégratif de génomique (CIG) de la Faculté de biologie et de médecine de l’UNIL, le Prof. Alexandre Reymond a été élu Président de la Société européenne de génétique humaine le 16 juin 2019 à Göteborg, en Suède.

Fondée en 1967, la Société européenne de génétique humaine (European Society of Human Genetics – ESHG) est une organisation non gouvernementale forte de quelque 3’500 membres. Elle promeut la recherche fondamentale et appliquée dans les domaines de la génétique humaine et médicale. Elle garantit de hauts standards dans le diagnostic et la pratique cliniques.

Grâce à son réseau étendu, la Société facilite les contacts entre les scientifiques qui partagent ces mêmes objectifs, plus spécifiquement ceux vivant en Europe. L’organisation d’un congrès annuel au printemps, qui réunit plus de 4’000 spécialistes de la génétique humaine issus de plus de 80 pays, constitue un bon exemple d’événement rassembleur.

Further information on the ESHG: https://www.eshg.org/index.php?id=home 
Further information on the election: https://news.unil.ch/display/1559818783379

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C.Fankhauser will be on Einstein TV program, SRF channel, on June 27, 2019 at 10:25pm

Plants have neither nerves nor eyes or ears. Nevertheless, they perceive their environment precisely and actively react to environmental influences. “Einstein” shows surprising sensory performances of plants and asks the question: Do they even have their own consciousness?

Link to the TV program: https://www.srf.ch/programm/tv/sendung/P30707403527_T143209146812?ns_source=web

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Thesis defense of Judit CASTILLO ARMENGOL, June 24, 2019 – 4:30 pm in Aud. A, Génopode

Madame Judit CASTILLO ARMENGOL soutiendra en vue de l’obtention du grade de Doctorat ès sciences de la vie (PhD) de l’Université de Lausanne sa thèse intitulée “CDK4 as a novel regulator of brown adipose tissue biology”

Directeur de thèse : Monsieur le Professeur Lluis FAJAS COLL

Cette soutenance aura lieu le Lundi 24 juin 2019 à 16h30 dans l’Aud. A du Génopode.