Nucleic Acids Res.: Group Stasiak

Nucleic Acids Res. 2010 Jul 31. [Epub ahead of print]

The role of transcription factories-mediated interchromosomal contacts in the organization of nuclear architecture.

Dorier J, Stasiak A.

Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015-Lausanne, Switzerland.

Abstract: Using numerical simulations, we investigate the underlying physical effects responsible for the overall organization of chromosomal territories in interphase nuclei. In particular, we address the following three questions: (i) why are chromosomal territories with relatively high transcriptional activity on average, closer to the centre of cell’s nucleus than those with the lower activity? (ii) Why are actively transcribed genes usually located at the periphery of their chromosomal territories? (iii) Why are pair-wise contacts between active and inactive genes less frequent than those involving only active or only inactive genes? We show that transcription factories-mediated contacts between active genes belonging to different chromosomal territories are instrumental for all these features of nuclear organization to emerge spontaneously due to entropic effects arising when chromatin fibres are highly crowded.

J. Chem. Phys.; auth.: Group Stasiak

Kenneth C. Millett1, Eric J. Rawdon2, Vy T. Tran3, and Andrzej Stasiak4

1Department of Mathematics, University of California Santa Barbara, California 93106, USA
2Department of Mathematics, University of St. Thomas, Saint Paul, Minnesota 55105, USA
3Department of Physics, Washington University, Saint Louis, Missouri 63130, USA
4Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH 1015, Switzerland

(Received 12 July 2010; accepted 9 September 2010; published online 20 October 2010)

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J Med Chem; co-auth: A.Stasiak

J Med Chem. 2010 Aug 12;53(15):5782-91.

Design of Potent Inhibitors of Human RAD51 Recombinase Based on BRC Motifs of BRCA2 Protein: Modeling and Experimental Validation of a Chimera Peptide.

Nomme J, Renodon-Cornière A, Asanomi Y, Sakaguchi K, Stasiak AZ, Stasiak A, Norden B, Tran V, Takahashi M.

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Molecular Cell (Featured); co-auth.: Group Stasiak

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

Zhijiang Yan,Mathieu Delannoy,Chen Ling,Danielle Daee,Fekret Osman,Parameswary A. Muniandy,Xi Shen,Anneke B. Oostra,Hansen Du,Jurgen Steltenpool,Ti Lin,Beatrice Schuster,Chantal Décaillet,Andrzej Stasiak,Alicja Z. Stasiak,Stacie Stone,Maureen E. Hoatlin,Detlev Schindler,Christopher L. Woodcock,Hans Joenje,Ranjan Sen,Johan P. de Winter,Lei Li,Michael M. Seidman,Matthew C. Whitby,Kyungjae Myung,Angelos Constantinou,Weidong Wang See Affiliations

this paper is “must read” on Faculty 1000
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