Metabolism, co-auth.: W.Wahli

GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway

Javier Jurado-Aguilar 1Emma Barroso 1Maribel Bernard 1Meijian Zhang 1Mona Peyman 1Patricia Rada 2Ángela M Valverde 2Walter Wahli 3Xavier Palomer 1Manuel Vázquez-Carrera 4

. 2024 Jan 3:152:155772.

 doi: 10.1016/j.metabol.2023.155772. Online ahead of print.


Introduction: The levels of the cellular energy sensor AMP-activated protein kinase (AMPK) have been reported to be decreased via unknown mechanisms in the liver of mice deficient in growth differentiation factor 15 (GDF15). This stress response cytokine regulates energy metabolism mainly by reducing food intake through its hindbrain receptor GFRAL.