Metabolism, co-auth.: W.Wahli

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GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway

Javier Jurado-Aguilar 1, Emma Barroso 1, Maribel Bernard 1, Meijian Zhang 1, Mona Peyman 1, Patricia Rada 2, Ángela M Valverde 2, Walter Wahli 3, Xavier Palomer 1, Manuel Vázquez-Carrera 4

. 2024 Jan 3:152:155772.

 doi: 10.1016/j.metabol.2023.155772. Online ahead of print.

Abstract

Introduction: The levels of the cellular energy sensor AMP-activated protein kinase (AMPK) have been reported to be decreased via unknown mechanisms in the liver of mice deficient in growth differentiation factor 15 (GDF15). This stress response cytokine regulates energy metabolism mainly by reducing food intake through its hindbrain receptor GFRAL.