Feb 1 17:00 Biophore
Regulation of metazoan cell proliferation
Two complete sets of instructions contained within the genomes we inherit from our parents are responsible for directing a single cell – the zygote – to become an adult human being. This process results from controlled patterns of gene expression that are maintained as well as changed during many rounds of cell division, differentiation, and death. Control of gene transcription is fundamental to these processes, with genetic and epigenetic defects in transcriptional regulation often leading to human disease including cancer. We elucidate these processes in animals by studying a metazoan-specific coordinator of epigenetic control called HCF-1.