Seminars & Workshops Archive

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SPECIAL SEMINAR, April 28, 2021

The Department of Fundamental Microbiology and the Faculty of Biology and Medicine present a “special seminar” about the Dubochet Center for Imaging at UNIL-EPFL.

«Recent and ongoing developments in cryogenic
electron microscopy at UNIL and EPFL»
by Pr Henning Stahlberg

with the participation of Dre Christel Genoud and an introduction by Dean Jean-Daniel Tissot.

Wednesday 28th, April 2021, 16:15
Virtually on ZOOM: https://unil.zoom.us/j/8328613128

Followed by Question & Answer session

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Career roundtable in plant sciences and ecology, May 26, 2021 at 6:30 p.m.

 ADAS in collaboration with Skills for Scientists are organising a round table in plant sciences and ecology on May 26, 2021 at 6:30 p.m.

This roundtable discussion will feature 4 scientists including 2 alumni from the FBM that will talk about their career paths and current roles. The event is aimed at young researchers who wish to learn more about the diversity of careers that are available following in the field of Plant Sciences and Ecology.

The confirmed panelists are:
Sebastian Soyk, PI & Assistant Professor at the CIG, UNIL
Moises Exposito-Alonso, PI & Assistant Professor (by courtesy) at the Carnegie Department of Plant Biology, Stanford, USA
Ramona Maggini, Plant Protection, Research group South of the Alps at Agroscope, Ticino
Andrzej Kurenda, Chief Scientific Officer (CSO) at Vivent SARL, Lausanne

Free registration on https://conference.unil.ch/cours/fbm (event limited to 25 participants)

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DBMV – Internal seminar

Dr Alessandra Boccaccini will give a seminar on Tuesday April 13, 2021 at 12:15 p.m
Neighbors detection and transcriptional reprogramming: what’s new?

Category Archives: People | Page 34

>>> Zoom-link to access the seminar <<<

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Swiss Young Immunologists Society – Spring Seminar Series 2021

Join us for the Swiss Young Immunologists Society (SYIS) Seminar Series!

Every third Thursday of the month at 5pm we will host an online seminar. This series alternates Science talks by young PIs/senior PostDocs in the field of immunology, and Soft-Skill workshops that will help you preparing for your career path to becoming a PI.
Check out the program (attached) and don’t forget to sign up!

Best wishes,

The SYIS team

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Filipa Marques Ferreira, PhD
Institute of Laboratory Animal Sciences
Wagistrasse 12, 8952 Schlieren

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Mon June 28, 2021 CIG Sem. S. Manley

CIG Seminars Spring 2021

Monday 12:15, Génopode, auditorium B (or online, will be decided in due time)

Free entrance

Download the poster

Monday June 28, 2021
Suliana Manley, EPFL, Lausanne, Switzerland
«TBA»
Host: Maria C. Gambetta

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DNF Seminar: Prof. Alexandre Reymond will give a talk on Feb. 18,2021

This event will take place on a virtual space on 
Thursday, February 18th at 12:15 through the following Zoom link:
https://unil.zoom.us/j/2636884125

Alexandre Reymond, CIG – UNIL
 “Genome architecture and disease: the 16p11.2 paradigm” 

Abstract:

The recurrent 600 kbp deletions and duplications at human chromosome 16p11.2 are among the most frequent genetic causes of neurodevelopmental and psychiatric disorders, as they are found in 1% of individuals with autism spectrum disorders and schizophrenia. These rearrangements cause reciprocal defects in head size, body weight and as described below age of menarche (AaM).

These rearrangements are mediated by human-specific duplications that appeared at the beginning of the modern human lineage, suggesting that their expansion has a possible evolutionary advantage that outweighs the accompanying chromosomal instability. These duplications include BOLA2, a gene involved in the maturation of cytosolic iron-sulfur proteins. To investigate the potential advantage provided by its rapid expansion, we assessed hematological traits in individuals who have lost or gained copies of BOLA2. The 16p11.2 deletion is strongly associated with anemia (P=4e-7, OR=5) and upon stratification by BOLA2 copy number, we found an association between low BOLA2 dosage and anemia (P=2e-3). Consistent with human data, the 16p11.2 deletion mouse model and Bola2-deficient mice showed early evidence of iron deficiency. The rapid expansion of BOLA2 might have evolved to protect humans against iron deficiency as our species successfully expanded its ecological range at the cost of increased predisposition to rearrangements associated with autism.

We leveraged biobank-scale phenotype data, Mendelian randomization and animal modeling to identify causative genes in a GWAS locus for AaM. The dosage of the 16p11.2 interval is correlated with AaM and an increase in reproductive tract disorders. Likewise, 16p11.2 mouse models display perturbed pubertal onset and structurally altered reproductive organs. Further, we report a negative correlation between the 16p11.2 dosage and relative hypothalamic volume in both humans and mice, intimating a perturbation in the gonadotropin-releasing hormone (GnRH) axis. Two independent assays identified candidate causal genes for AaM; Mendelian randomization and agnostic dosage modulation of each 16p11.2 gene in zebrafish gnrh3:egfp models. ASPHD1, expressed predominantly in brain and pituitary gland, emerged as a major phenotype driver; and it is subject to modulation by KCTD13 to exacerbate GnRH neuron phenotype. Together, our data highlight the power of an interdisciplinary approach to elucidate disease etiologies underlying complex traits.