Seminars & Workshops Archive

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Thesis defense of Maxime Jan, May 18, 2018 – 17:00 Aud. A, Génopode

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Mon June 4, 2018 BIG Sem. A. Brand

BIG seminars 2017-2018 (download poster)

Every first Monday of the month
16h15, Auditorium Biophore Building
UniL-Sorge at Dorigny
BIG is an interdepartmental seminar series, and is organized by Ted Farmer, Thomas Flatt, Winship Herr and Sophie Martin
4 June 2018  Andrea Brand, The Gurdon Institute
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11th Leena Peltonen School of Human Genomics, Aug. 19-23, 2018, Les Diablerets

Leena Peltonen School of Human Genomics 2018

August 19-23, 2018, Les Diablerets, Switzerland (www.eurotel-victoria.ch).

Scientific programme committee:

Nancy Cox, Vanderbilt University, USA
Manolis Dermitzakis, University of Geneva, Switzerland
Mark McCarthy, University of Oxford, UK

Confirmed tutors:

Nicholas Katsanis, Duke University, USA
Cecilia Lindgren, University of Oxford, UK
Ruth Loos, Mount Sinai Hospital, USA
Len Pennacchio, Lawrence Berkeley National Laboratory, USA
Cisca Wijmenga, University Medical Center Groningen, The Netherlands
Tuuli Lappalainen, NYGC and Columbia University, USA
Alexandre Reymond, University of Lausanne, Switzerland
Magdalena Skipper, Nature Communications
Gosia Trynka, Sanger Institute, UK
Jacques Fellay, CHUV and EPFL, Switzerland
Jonathan Marchini, Oxford University, UK
Samuli Ripatti, University of Helsinki, Finland
Lude Franke, University of Groningen, The Netherlands
Stylianos Antonarakis, University of Geneva, Switzerland

Description:

We are pleased to announce the 11th Leena Peltonen School of Human Genomics 2018 to take place for the first time in the Swiss alps, in Les Diablerets. This summer school provides a unique opportunity to learn and be inspired by those that have shaped our understanding of human genomics in the past decade. Now in its ninth year, it was re-named ‘The Leena Peltonen School of Human Genomics’ in 2011, as a tribute to Leena Peltonen. Tutors at the school are among the scientific leaders who are advancing the field of human genomics, and former students are now at the forefront of much of this research.

This is a uniquely fascinating time in human genetics and genomics, as the field moves beyond the cataloguing of associated variation towards fundamental biological inference and translational implementation. The programme will cover a range of topics including our current understanding of the genomics of rare and complex human diseases. There will be sessions addressing gene regulation and functional analysis. The latest advances in sequencing technology and the future of whole genome and clinical sequencing will also be discussed.

The schedule is highly interactive with presentations by the tutors and students on cutting-edge topics in human genomics. The summer school is more akin to a ‘science summer camp’ for graduate students with discussions and debates on the future of human genomics. A unique feature is the one-to-one mentoring on all aspects of genomics, including advice on publishing and pursuing an academic research career.

The summer school is suitable for scientists and clinicians undertaking graduate studies focused on human genetics and genomics. Applications from those who have completed a PhD in another area and have moved into genomics for their postdoctoral studies will also be considered. To optimize discussions and interactions, numbers are limited to 20 students.

Registration

Please apply at: application form (gmail account required)
Please submit as a single PDF the following:

  • Up to 250 words of motivation
  • A short CV
  • A short support letter by your PhD advisor

Deadline: May 31, 2018
Cost: 800 CHF (covers accommodation and meals)
Applications will be selected and announced to applicants by June 15, 2018

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Jim Wilson will give a seminar – 4pm. Aud. B, Génopode on May 17, 2018

Jim Wilson seminar

Place: Genopode Auditorium B

Time: 16h00, 17 May

Title: The Scope and Mechanism of Inbreeding Depression in Humans

Abstract: In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is rare in many cultures and frequently associated with confounding social factors. Moreover, it is not certain which of the classical rival theories of dominance or overdominance (heterozygote advantage) is the principal mechanism underlying these effects. Here, using genomic inbreeding coefficients (FROH) for >1.3 million individuals, we show that FROH is significantly associated (P < 0.0005) with changes in 31 of 101 complex traits analysed. An increase in FROH is associated with reduced reproductive success (ever having children, age at first birth, age at first sex, number of sexual partners), as well as reduced alcohol intake, likelihood of ever-smoking and self-reported risk taking, and increases in disease risk factors (including heart rate and lymphocyte percentage). The resultant effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% increase [95% CI 44-66%] in the odds of remaining childless. These effects are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants causing inbreeding depression are rare, consistent with the dominance hypothesis. Moreover, for a subset of traits, the effect of FROH differs significantly between men and women. Indeed, increasing FROH significantly decreases total and LDL cholesterol in men, and is thus cardio-protective in this regard. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in genomic inbreeding is independent of environmental confounding. The fact that autozygosity caused by inbreeding influences a broad range of human phenotypes, some positively, others negatively, suggests a complex history of selection.

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Cancelled Mon May 14, 2018 BIG Sem. J. Chory

BIG seminars 2017-2018

Every first Monday of the month
16h15, Auditorium Biophore Building
UniL-Sorge at Dorigny
BIG is an interdepartmental seminar series, and is organized by Ted Farmer, Thomas Flatt, Winship Herr and Sophie Martin
14 May 2018  Joanne Chory, Salk Institute CANCELLED
“Fifty shades of shade: Adaptation of plants to their local environment”
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Mon May 28, 2018 CIG Sem. I. Miguel-Aliaga

CIG Seminars Spring 2018

Monday 12:15, Génopode, auditorium A, followed by sandwiches

Download the poster

 

 

Monday May 28, 2018
Irene Miguel-Aliaga, Imperial College, London, UK
«Hungry brains and clever guts»
Host: Richard Benton